NLR-Associating Transcription Factor bHLH84 and Its Paralogs Function Redundantly in Plant Immunity

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In plants and animals, NLR immune receptors are utilized to detect pathogen-derived molecules and activate immunity. However, the mechanisms of plant NLR activation remain unclear. Here, we report on bHLH84, which functions as a transcriptional activator. Simultaneously knocking out three closely related bHLH paralogs partially suppresses the autoimmunity of snc1 and compromises RPS4-mediated defense, while overexpression of these close paralogs renders strong autoimmunity, suggesting functional redundancy in the gene family. In planta co-immunoprecipitation revealed interactions between not only bHLH84 and SNC1, but also bHLH84 and RPS4. Therefore bHLH84 family transcription factors associate with these NLRs to activate defense responses, enabling potentially faster and more robust transcriptional reprogramming upon pathogen recognition.

Vyšlo v časopise: NLR-Associating Transcription Factor bHLH84 and Its Paralogs Function Redundantly in Plant Immunity. PLoS Pathog 10(8): e32767. doi:10.1371/journal.ppat.1004312
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004312

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