Ethanolamine Signaling Promotes Niche Recognition and Adaptation during Infection

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Chemical signaling underlies all cellular processes. Bacteria rely on chemical signaling to gain information about the local environment and precisely regulate gene expression. Ethanolamine is an abundant molecule within mammalian hosts that plays an important role in mammalian physiology and also serves as a carbon and nitrogen source for bacteria. Here we show that the foodborne pathogen Salmonella enterica exploits ethanolamine as a signal of distinct host environments to coordinate metabolism and virulence, which enhances disease progression during infection. The ability to sense ethanolamine is conserved in diverse bacteria; thus, these studies reveal that ethanolamine signaling may be important for bacterial adaptation to the mammalian host.

Vyšlo v časopise: Ethanolamine Signaling Promotes Niche Recognition and Adaptation during Infection. PLoS Pathog 11(11): e32767. doi:10.1371/journal.ppat.1005278
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005278

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