Parasite Glycobiology: A Bittersweet Symphony

1. Hotez PJ, Alvarado M, Basáñez M-G, Bolliger I, Bourne R, Boussinesq M, et al. The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases. PLoS Negl Trop Dis. 2014;8: e2865. doi: 10.1371/journal.pntd.0002865 25058013

2. Ferguson MA. The surface glycoconjugates of trypanosomatid parasites. Philos Trans R Soc Lond B Biol Sci. 1997;352: 1295–302. 9355120

3. Van Die I, Cummings RD. Glycan gimmickry by parasitic helminths: a strategy for modulating the host immune response? Glycobiology. 2010;20: 2–12. doi: 10.1093/glycob/cwp140 19748975

4. Kuijk LM, Klaver EJ, Kooij G, van der Pol SMA, Heijnen P, Bruijns SCM, et al. Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation. Mol Immunol. 2012;51: 210–8. doi: 10.1016/j.molimm.2012.03.020 22482518

5. Samuelson J, Robbins P. A simple fibril and lectin model for cyst walls of Entamoeba and perhaps Giardia. Trends Parasitol. 2011;27: 17–22. doi: 10.1016/j.pt.2010.09.002 20934911

6. Nyame AK, Kawar ZS, Cummings RD. Antigenic glycans in parasitic infections: implications for vaccines and diagnostics. Arch Biochem Biophys. 2004/05/26 ed. 2004;426: 182–200. 15158669

7. Ferguson MA. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. J Cell Sci. 1999;112 (Pt 1: 2799–2809.

8. Parodi AJ. N-glycosylation in trypanosomatid protozoa. Glycobiology. 1993;3: 193–199. 8358146

9. Samuelson J, Robbins PW. Effects of N-glycan precursor length diversity on quality control of protein folding and on protein glycosylation. Semin Cell Dev Biol. 2014;41: 121–128. doi: 10.1016/j.semcdb.2014.11.008 25475176

10. McConville MJ, Thomas-Oates JE, Ferguson MA, Homans SW. Structure of the lipophosphoglycan from Leishmania major. J Biol Chem. 1990;265: 19611–19623. http://www.jbc.org/content/265/32/19611.short 2246247

11. Turnock DC, Ferguson MAJ. Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Eukaryot Cell. 2007;6: 1450–63. 17557881

12. Sanz S, Bandini G, Ospina D, Bernabeu M, Mariño K, Fernández-Becerra C, et al. Biosynthesis of GDP-fucose and other sugar nucleotides in the blood stages of Plasmodium falciparum. J Biol Chem. 2013;288: 16506–17. doi: 10.1074/jbc.M112.439828 23615908

13. Güther MLS, Urbaniak MD, Tavendale A, Prescott A, Ferguson MAJ. High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics. J Proteome Res. American Chemical Society; 2014;13: 2796–806.

14. Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B. The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res. 2009;37: D233–8. doi: 10.1093/nar/gkn663 18838391

15. Damerow M, Rodrigues JA, Wu D, Güther MLS, Mehlert A, Ferguson MAJ. Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei. J Biol Chem. 2014;289: 9328–39. d doi: 10.1074/jbc.M114.555029 24550396

16. Titz A, Butschi A, Henrissat B, Fan Y-Y, Hennet T, Razzazi-Fazeli E, et al. Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. J Biol Chem. 2009;284: 36223–33. doi: 10.1074/jbc.M109.058354 19858195

17. Izquierdo L, Schulz BL, Rodrigues JA, Guther ML, Procter JB, Barton GJ, et al. Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases. Embo J. 2009/07/25 ed. 2009;28: 2650–2661. doi: 10.1038/emboj.2009.203 19629045

18. Paschinger K, Wilson IBH. Glycoscience: Biology and Medicine [Internet]. Taniguchi N, Endo T, Hart GW, Seeberger PH, Wong C-H, editors. Tokyo: Springer Japan; 2015.

19. Schiller B, Hykollari A, Yan S, Paschinger K, Wilson IBH. Complicated N-linked glycans in simple organisms. Biol Chem. 2012;393: 661–73. doi: 10.1515/hsz-2012-0150 22944671

20. Izquierdo L, Güther MLS, Ferguson MAJ. Creation and characterization of glycosyltransferase mutants of Trypanosoma brucei. Methods Mol Biol. 2013;1022: 249–75. doi: 10.1007/978-1-62703-465-4_19 23765667

21. Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings C V, et al. Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010;9: 228–41. doi: 10.1128/EC.00197-09 19783771

22. Yilmaz B, Portugal S, Tran TM, Gozzelino R, Ramos S, Gomes J, et al. Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission. Cell. 2014;159: 1277–1289. doi: 10.1016/j.cell.2014.10.053 25480293

23. De Andrade AL, Zicker F, de Oliveira RM, Almeida Silva S, Luquetti A, Travassos LR, et al. Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet. 1996/11/23 ed. 1996;348: 1407–1413. 8937280

24. Acosta-Serrano A, Cole RN, Mehlert A, Lee MG, Ferguson MA, Englund PT. The procyclin repertoire of Trypanosoma brucei. Identification and structural characterization of the Glu-Pro-rich polypeptides. J Biol Chem. 1999 Oct 15;274(42): 29763–71. 10514452