Tipping the Balance in the Powerhouse of the Cell to “Protect” Colorectal Cancer

1. CairnsRAHarrisIMcCrackenSMakTW 2011 Cancer cell metabolism. Cold Spring Harb Symp Quant Biol E-pub ahead of print 12 December 2011

2. LoebLASpringgateCFBattulaN 1974 Errors in DNA replication as a basis of malignant changes. Cancer Res 34 2311 2321

3. MoolgavkarSHLuebeckEG 2003 Multistage carcinogenesis and the incidence of human cancer. Genes Chromosomes Cancer 38 302 306

4. Abu-AmeroKKAlzahraniASZouMShiY 2005 High frequency of somatic mitochondrial DNA mutations in human thyroid carcinomas and complex I respiratory defect in thyroid cancer cell lines. Oncogene 24 1455 1460

5. AlonsoAMartinPAlbarranCAquileraBGarciaO 1997 Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single-strand conformation analysis. Electrophoresis 18 682 685

6. LiuVWShiHHCheungANChiuPMLeungTW 2001 High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas. Cancer Res 61 5998 6001

7. MontaniniLRegna-GladinCEoliMAlbarosaRCarraraF 2005 Instability of mitochondrial DNA and MRI and clinical correlations in malignant gliomas. J Neurooncol 74 87 89

8. NagyAWilhelmMKovacsG 2003 Mutations of mtDNA in renal cell tumours arising in end-stage renal disease. J Pathol 199 237 242

9. NomotoSYamashitaKKoshikawaKNakaoASidranskyD 2002 Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma. Clin Cancer Res 8 481 487

10. PetrosJABaumannAKRuiz-PesiniEAminMBSunCQ 2005 mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci U S A 102 719 724

11. Sanchez-CespedesMAhrendtSAPiantadosiSRosellRMonzoM 2001 Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res 61 1309 1313

12. TanDJBaiRKWongLJ 2002 Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer. Cancer Res 62 972 976

13. WuCWYinPHHungWYLiAFLiSH 2005 Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosomes Cancer 44 19 28

14. Modica-NapolitanoJSSinghKK 2004 Mitochondrial dysfunction in cancer. Mitochondrion 4 755 762

15. SinghKKKulawiecMStillIDesoukiMMGeradtsJ 2005 Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene 354 140 146

16. CopelandWCWachsmanJTJohnsonFMPentaJS 2002 Mitochondrial DNA alterations in cancer. Cancer Invest 20 557 569

17. CarewJSHuangP 2002 Mitochondrial defects in cancer. Mol Cancer 1 9

18. BielasJHLoebLA 2005 Quantification of random genomic mutations. Nat Methods 2 285 290

19. EricsonNGKulawiecMVermulstMSheahanKO'SullivanJ 2012 Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genet 8 e1002689 doi:10.1371/journal.pgen.1002689

20. WarburgO 1956 On the origin of cancer cells. Science 123 309 314

21. WarburgO 1956 On respiratory impairment in cancer cells. Science 124 269 270

22. WardPSThompsonCB 2012 Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21 297 308

23. ElstromRLBauerDEBuzzaiMKarnauskasRHarrisMH 2004 Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64 3892 3899

24. LiuPDempleB 2010 DNA repair in mammalian mitochondria: Much more than we thought? Environ Mol Mutagen 51 417 426

25. AkbariMVisnesTKrokanHEOtterleiM 2008 Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis. DNA Repair (Amst) 7 605 616

26. FukuiHMoraesCT 2009 Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Hum Mol Genet 18 1028 1036

27. KraytsbergYSchwartzMBrownTAEbralidseKKunzWS 2004 Recombination of human mitochondrial DNA. Science 304 981

28. HamanakaRBChandelNS 2011 Cell biology. Warburg effect and redox balance. Science 334 1219 1220

29. SattlerUGMueller-KlieserW 2009 The anti-oxidant capacity of tumour glycolysis. Int J Radiat Biol 85 963 971

30. IzyumovDSAvetisyanAVPletjushkinaOYSakharovDVWirtzKW 2004 “Wages of fear”: transient threefold decrease in intracellular ATP level imposes apoptosis. Biochim Biophys Acta 1658 141 147

31. Munoz-PinedoCRuiz-RuizCRuiz de AlmodovarCPalaciosCLopez-RivasA 2003 Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing. J Biol Chem 278 12759 12768