The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult .

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C. elegans provides a tractable genetic model to study the regulation of the evolutionarily conserved innate immune system. One of the central signaling modules of innate immunity in all organisms is the p38 pathway, which has been studied extensively in C. elegans. Such studies identified the transcription factors ATF-7 and SKN-1 as proteins mediating downstream effects of the p38 pathway on immune and oxidative stress gene expression. Previous studies in C. elegans also identified ELT-2, a conserved transcription factor important for intestinal development, as a major regulator of immune responses in the adult worm. The current study aimed to characterize the interactions between these two immune regulatory modules. Microarray gene expression analysis in animals with disrupted elt-2 expression revealed two gene subsets that were regulated by elt-2: one that included constitutively regulated genes, and was mostly comprised of digestive enzyme genes, and a second that included genes induced by infection with Pseudomonas aeruginosa. Both subsets were enriched for p38 targets. Genetic analyses and gene expression measurements of elt-2-regulated genes demonstrated that elt-2 cooperates with the p38 pathway and its downstream mediators. These results suggest that ELT-2 functions as a tissue-specific master regulator controlling the contribution of the p38 MAPK pathway to innate immune responses.

Vyšlo v časopise: The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult .. PLoS Genet 11(5): e32767. doi:10.1371/journal.pgen.1005265
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005265

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