P47 Mice Are Compromised in Expansion and Activation of CD8 T Cells and Susceptible to Infection

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Macrophage activation of NADPH oxidase NOX2) and reactive oxygen species (ROS) is suggested to mediate control of Trypanosoma cruzi infection that is the causative agent of Chagas disease. However, how NOX2/ROS deficiency affects parasite persistence and chronic disease is not known. In this study, we present the first evidence that NOX2 and ROS shape the T cell-mediated adaptive immunity, and its deficiency result in compromised splenic activation of type 1 cytotoxic CD8+ T cell response to T. cruzi infection. Subsequently, p47phox−/− mice that lack NOX2 activity were more unable to control parasite replication and dissemination and succumbed to susceptible to T. cruzi infection. Our study highlights how redox state of innate immune cells alters the adaptive immunity to intracellular pathogens; and suggests that understanding the molecular and cellular mechanisms affected by redox state of immune cells at basal level could be exploited in designing future therapeutic and vaccination strategies against T. cruzi infection and Chagas disease.

Vyšlo v časopise: P47 Mice Are Compromised in Expansion and Activation of CD8 T Cells and Susceptible to Infection. PLoS Pathog 10(12): e32767. doi:10.1371/journal.ppat.1004516
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004516

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