New Insights into How Adapts to Its Mammalian Host during Bubonic Plague

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In order to understand and combat infectious diseases, it is essential to characterize the full set of genes required by pathogenic bacteria to overcome the many immunological and physiological challenges encountered during infection. Here, we used a genome-scale approach to identify genes required by the bacterium Yersinia pestis in the production of bubonic plague (a fatal, flea-borne zoonosis). Our results suggest that when colonizing the mammalian host, the bacterium (i) relies on carbohydrates as its carbon source, (ii) shifts to anaerobic respiration or fermentation and (iii) experiences and resists several (but not all) types of stress generated by the host's innate immune system. Strikingly, only a small set of genes (including horizontally acquired and uncharacterized sequences) are required for these infectious processes. Further investigations of the ypmt1,66c gene provided evidence to suggest that accretion of genetic material via horizontal transfer has played a key role in Yersinia pestis' ability to successfully initiate infection after the dermal fleabite. Lastly, we believe that (i) application of our approach to other pathogens and (ii) additional studies of selected Yersinia pestis genes important for plague pathogenesis (some of which are shared with other pathogens) will provide a better understanding of bacterial pathogenesis in general.

Vyšlo v časopise: New Insights into How Adapts to Its Mammalian Host during Bubonic Plague. PLoS Pathog 10(3): e32767. doi:10.1371/journal.ppat.1004029
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004029

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