Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza

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Annual epidemics of influenza result in 3 to 5 million cases of severe illness and approximately 300,000 deaths around the world. Although most patients infected with normal circulating influenza A viruses recover from the illness, complications arise during infections with highly pathogenic strains of the virus, resulting in increased mortality associated with severe immunopathology and acute respiratory distress. Previous studies suggested a major contribution of the vigorous immune response to lung damage. How the immune system constrains the negative impact of inflammation might therefore be of significant importance for future therapies. Our study in a mouse model of influenza shows that the cytokine IL-27 plays a crucial role in survival by protecting against lung damage. Its actions include regulation of innate (neutrophil influx) and adaptive (inflammatory cytokine production of T cells) arms of immunity during the acute respiratory infection. The data also suggest a therapeutic potential of IL-27, as mice treated with recombinant cytokine at later stages of infection exhibited decreased immunopathology and showed improved survival. The findings uncover an important role of IL-27 in limiting the collateral damages of anti-viral immunity and provide initial evidence that these mechanisms might be exploited for the management of severe immunopathology after infection.

Vyšlo v časopise: Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza. PLoS Pathog 10(5): e32767. doi:10.1371/journal.ppat.1004110
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004110

Souhrn

Zdroje

1. BarryJM (2004) The site of origin of the 1918 influenza pandemic and its public health implications. J Transl Med 2: 3.

2. WebbyRJ, WebsterRG (2003) Are we ready for pandemic influenza? Science 302: 1519–1522.

3. PeirisJS, HuiKP, YenHL (2010) Host response to influenza virus: protection versus immunopathology. Current opinion in immunology 22: 475–481.

4. La GrutaNL, KedzierskaK, StambasJ, DohertyPC (2007) A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol 85: 85–92.

5. TisoncikJR, KorthMJ, SimmonsCP, FarrarJ, MartinTR, et al. (2012) Into the eye of the cytokine storm. Microbiol Mol Biol Rev 76: 16–32.

6. BuckleyCD, GilroyDW, SerhanCN, StockingerB, TakPP (2013) The resolution of inflammation. Nat Rev Immunol 13: 59–66.

7. PflanzS, TimansJC, CheungJ, RosalesR, KanzlerH, et al. (2002) IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells. Immunity 16: 779–790.

8. HunterCA (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 5: 521–531.

9. HibbertL, PflanzS, De Waal MalefytR, KasteleinRA (2003) IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res 23: 513–522.

10. ChenQ, GhilardiN, WangH, BakerT, XieMH, et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407: 916–920.

11. YoshidaH, HamanoS, SenaldiG, CoveyT, FaggioniR, et al. (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15: 569–578.

12. StumhoferJS, HunterCA (2008) Advances in understanding the anti-inflammatory properties of IL-27. Immunology letters 117: 123–130.

13. FindlayEG, GreigR, StumhoferJS, HafallaJC, de SouzaJB, et al. (2010) Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection. Journal of immunology 185: 2482–2492.

14. RosasLE, SatoskarAA, RothKM, KeiserTL, BarbiJ, et al. (2006) Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology. Am J Pathol 168: 158–169.

15. StumhoferJS, LaurenceA, WilsonEH, HuangE, TatoCM, et al. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature Immunology 7: 937–945.

16. HolscherC, HolscherA, RuckerlD, YoshimotoT, YoshidaH, et al. (2005) The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol 174: 3534–3544.

17. HamanoS, HimenoK, MiyazakiY, IshiiK, YamanakaA, et al. (2003) WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 19: 657–667.

18. VillarinoA, HibbertL, LiebermanL, WilsonE, MakT, et al. (2003) The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19: 645–655.

19. Amadi-ObiA, YuCR, LiuX, MahdiRM, ClarkeGL, et al. (2007) TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 13: 711–718.

20. BattenM, LiJ, YiS, KljavinNM, DanilenkoDM, et al. (2006) Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7: 929–936.

21. YoshimuraT, TakedaA, HamanoS, MiyazakiY, KinjyoI, et al. (2006) Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J Immunol 177: 5377–5385.

22. RutzS, JankeM, KassnerN, HohnsteinT, KruegerM, et al. (2008) Notch regulates IL-10 production by T helper 1 cells. Proc Natl Acad Sci U S A 105: 3497–3502.

23. SunJ, DoddH, MoserEK, SharmaR, BracialeTJ (2011) CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nature Immunology 12: 327–334.

24. OwakiT, AsakawaM, MorishimaN, HataK, FukaiF, et al. (2005) A role for IL-27 in early regulation of Th1 differentiation. J Immunol 175: 2191–2200.

25. LiuL, CaoZ, ChenJ, LiR, CaoY, et al. (2012) Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. The Journal of biological chemistry 287: 11899–11910.

26. MayerKD, MohrsK, ReileyW, WittmerS, KohlmeierJE, et al. (2008) Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection. J Immunol 180: 693–697.

27. SunJ, MadanR, KarpCL, BracialeTJ (2009) Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med 15: 277–284.

28. TateMD, IoannidisLJ, CrokerB, BrownLE, BrooksAG, et al. (2011) The role of neutrophils during mild and severe influenza virus infections of mice. PLoS One 6: e17618.

29. FitzgeraldDC, ZhangGX, El-BehiM, Fonseca-KellyZ, LiH, et al. (2007) Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 8: 1372–1379.

30. AwasthiA, CarrierY, PeronJP, BettelliE, KamanakaM, et al. (2007) A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 8: 1380–1389.

31. FitzgeraldDC, CiricB, TouilT, HarleH, GrammatikopolouJ, et al. (2007) Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. Journal of immunology 179: 3268–3275.

32. AndersonCF, StumhoferJS, HunterCA, SacksD (2009) IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. Journal of immunology 183: 4619–4627.

33. JankovicD, KuglerDG, SherA (2010) IL-10 production by CD4+ effector T cells: a mechanism for self-regulation. Mucosal Immunol 3: 239–246.

34. SaraivaM, ChristensenJR, VeldhoenM, MurphyTL, MurphyKM, et al. (2009) Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31: 209–219.

35. McKinstryKK, StruttTM, BuckA, CurtisJD, DibbleJP, et al. (2009) IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol 182: 7353–7363.

36. TumpeyTM, Garcia-SastreA, TaubenbergerJK, PaleseP, SwayneDE, et al. (2005) Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. J Virol 79: 14933–14944.

37. KuikenT, RiteauB, FouchierRA, RimmelzwaanGF (2012) Pathogenesis of influenza virus infections: the good, the bad and the ugly. Curr Opin Virol 2: 276–286.

38. ZhengBJ, ChanKW, LinYP, ZhaoGY, ChanC, et al. (2008) Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci U S A 105: 8091–8096.

39. SnelgroveRJ, GouldingJ, DidierlaurentAM, LyongaD, VekariaS, et al. (2008) A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol 9: 1074–1083.

40. KhoufacheK, LeBouderF, MorelloE, LaurentF, RiffaultS, et al. (2009) Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J Immunol 182: 7795–7802.

41. TeijaroJR, WalshKB, CahalanS, FremgenDM, RobertsE, et al. (2011) Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell 146: 980–991.

42. YoshidaH, MiyazakiY (2008) Regulation of immune responses by interleukin-27. Immunological reviews 226: 234–247.

43. MorishimaN, MizoguchiI, OkumuraM, ChibaY, XuM, et al. (2010) A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes. J Biomed Biotechnol 2010: 605483.

44. CroweCR, ChenK, PociaskDA, AlcornJF, KrivichC, et al. (2009) Critical role of IL-17RA in immunopathology of influenza infection. J Immunol 183: 5301–5310.

45. HsiehSM, ChangSC (2006) Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus. J Immunol 176: 4530–4533.

46. SchwarzenbergerP, HuangW, YeP, OliverP, ManuelM, et al. (2000) Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol 164: 4783–4789.

47. SchwarzenbergerP, La RussaV, MillerA, YeP, HuangW, et al. (1998) IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol 161: 6383–6389.

48. NembriniC, MarslandBJ, KopfM (2009) IL-17-producing T cells in lung immunity and inflammation. The Journal of allergy and clinical immunology 123: 986–994; quiz 995–986.

49. RajaiahR, PuttabyatappaM, PolumuriSK, MoudgilKD (2010) Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis. J Biol Chem 286: 2817–2825.

50. StumhoferJS, SilverJ, HunterCA (2007) Negative regulation of Th17 responses. Seminars in immunology 19: 394–399.

51. MurugaiyanG, MittalA, WeinerHL (2010) Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proc Natl Acad Sci U S A 107: 11495–11500.

52. KallioliasGD, GordonRA, IvashkivLB (2010) Suppression of TNF-alpha and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. Journal of immunology 185: 7047–7056.

53. BarlettaKE, CagninaRE, WallaceKL, RamosSI, MehradB, LindenJ (2012) Leukocyte compartments in the mouse lung: distinguishing between marginated, interstitial, and alveolar cells in response to injury. J Immunol Methods 375: 100–110.

54. TschernigT, PabstR (2009) What is the clinical relevance of different lung compartments? BMC Pulm Med 9: 39.

55. LiJP, WuH, XingW, YangSG, LuSH, et al. (2010) Interleukin-27 as a negative regulator of human neutrophil function. Scandinavian Journal of Immunology 72: 284–292.

56. LiuJ, GuanX, MaX (2007) Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-{gamma}-mediated pathways. J Exp Med 204: 141–152.

57. PirhonenJ, SirenJ, JulkunenI, MatikainenS (2007) IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages. J Leukoc Biol 82: 1185–1192.

58. RemoliME, GafaV, GiacominiE, SeveraM, LandeR, et al. (2007) IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur J Immunol 37: 3499–3508.

59. HeroldS, SteinmuellerM, von WulffenW, CakarovaL, PintoR, et al. (2008) Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand. J Exp Med 205: 3065–3077.

60. CaoJ, WangD, XuF, GongY, WangH, et al. (2014) Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia. EMBO Mol Med 6: 120–140..