Rapid Sequestration of by Neutrophils Contributes to the Development of Chronic Lesion

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Infection with the protozoan Leishmania parasites causes a spectrum of diseases ranging from cutaneous to visceral forms that are fatal if left untreated. Among the different Leishmania species, Leishmania mexicana causes chronic cutaneous lesions in humans. To study this disease, we used a murine model. Following infection with Leishmania mexicana, most mouse species including C57BL/6 develop chronic non-healing lesion. Within hours of infection, neutrophils are recruited locally and they ingest the parasites. Although neutrophils are leukocytes that are able to rapidly kill pathogens using an arsenal of molecules, several microorganisms including some, but not all, Leishmania species are able to survive within these cells. Here, we show that L. mexicana elicits the rapid recruitment of neutrophils at the site of infection, survives within these cells and uses them to its advantage. Furthermore, transient parasite sequestration by neutrophils delays recruitment of other leukocytes such as monocytes, contributing to the impaired development of a protective immune response against the parasite and chronic lesion development. Thus, we describe a previously unanticipated pathogenic role for neutrophils in chronic lesion development. More importantly, our data suggest that in certain forms of cutaneous leishmaniasis, regulating neutrophil recruitment could be a strategy to promote lesion healing.

Vyšlo v časopise: Rapid Sequestration of by Neutrophils Contributes to the Development of Chronic Lesion. PLoS Pathog 11(5): e32767. doi:10.1371/journal.ppat.1004929
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004929

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