Quaking Regulates Expression through Its 3′ UTR in Oligodendrocyte Precursor Cells

1. Lappe-SiefkeC

GoebbelsS

GravelM

NickschE

LeeJ

2003 Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet 33 366 374

2. GriffithsI

KlugmannM

AndersonT

YoolD

ThomsonC

1998 Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 280 1610 1613

3. LiC

TropakMB

GerlaiR

ClapoffS

Abramow-NewerlyW

1994 Myelination in the absence of myelin-associated glycoprotein. Nature 369 747 750

4. VernetC

ArtztK

1997 STAR, a gene family involved in signal transduction and activation of RNA. Trends Genet 13 479 484

5. SidmanRL

DickieMM

AppelSH

1964 Mutant Mice (Quaking and Jimpy) with Deficient Myelination in the Central Nervous System. Science 144 309 311

6. EbersoleT

RhoO

ArtztK

1992 The proximal end of mouse chromosome 17: new molecular markers identify a deletion associated with quakingviable. Genetics 131 183 190

7. HardyRJ

LoushinCL

FriedrichVLJr

ChenQ

EbersoleTA

1996 Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice. J Neurosci 16 7941 7949

8. ZhaoL

TianD

XiaM

MacklinWB

FengY

2006 Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI. J Neurosci 26 11278 11286

9. NoveroskeJK

HardyR

DapperJD

VogelH

JusticeMJ

2005 A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination. Mamm Genome 16 672 682

10. LiZ

ZhangY

LiD

FengY

2000 Destabilization and mislocalization of myelin basic protein mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins. J Neurosci 20 4944 4953

11. ZhaoL

KuL

ChenY

XiaM

LoPrestiP

2006 QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development. Mol Biol Cell 17 4179 4186

12. LarocqueD

GalarneauA

LiuHN

ScottM

AlmazanG

2005 Protection of p27(Kip1) mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation. Nat Neurosci 8 27 33

13. LarocqueD

PilotteJ

ChenT

CloutierF

MassieB

2002 Nuclear retention of MBP mRNAs in the quaking viable mice. Neuron 36 815 829

14. WuJI

ReedRB

GrabowskiPJ

ArtztK

2002 Function of quaking in myelination: regulation of alternative splicing. Proc Natl Acad Sci U S A 99 4233 4238

15. AbergK

SaetreP

LindholmE

EkholmB

PetterssonU

2006 Human QKI, a new candidate gene for schizophrenia involved in myelination. Am J Med Genet B Neuropsychiatr Genet 141 84 90

16. AbergK

SaetreP

JareborgN

JazinE

2006 Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia. Proc Natl Acad Sci U S A 103 7482 7487

17. McCullumsmithRE

GuptaD

BeneytoM

KregerE

HaroutunianV

2007 Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia. Schizophr Res 90 15 27

18. HaroutunianV

KatselP

DrachevaS

DavisKL

2006 The human homolog of the QKI gene affected in the severe dysmyelination “quaking” mouse phenotype: downregulated in multiple brain regions in schizophrenia. Am J Psychiatry 163 1834 1837

19. DrachevaS

ElhakemSL

MarcusSM

SieverLJ

McGurkSR

2003 RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia. J Neurochem 87 1402 1412

20. DrachevaS

DavisKL

ChinB

WooDA

SchmeidlerJ

2006 Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients. Neurobiol Dis 21 531 540

21. LawAJ

KleinmanJE

WeinbergerDR

WeickertCS

2007 Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia. Hum Mol Genet 16 129 141

22. SchmaussC

1996 Enhanced cleavage of an atypical intron of dopamine D3-receptor pre-mRNA in chronic schizophrenia. J Neurosci 16 7902 7909

23. KlempanTA

ErnstC

DelevaV

LabonteB

TureckiG

2009 Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder. Biol Psychiatry 66 824 831

24. BackxL

FrynsJP

MarcelisC

DevriendtK

VermeeschJ

2010 Haploinsufficiency of the gene Quaking (QKI) is associated with the 6q terminal deletion syndrome. Am J Med Genet A 152A 319 326

25. RyderSP

WilliamsonJR

2004 Specificity of the STAR/GSG domain protein Qk1: implications for the regulation of myelination. Rna 10 1449 1458

26. GalarneauA

RichardS

2005 Target RNA motif and target mRNAs of the Quaking STAR protein. Nat Struct Mol Biol 12 691 698

27. HafnerM

LandthalerM

BurgerL

KhorshidM

HausserJ

2010 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141 129 141

28. ZearfossNR

FarleyBM

RyderSP

2008 Post-transcriptional regulation of myelin formation. Biochim Biophys Acta 1779 486 494

29. LouisJC

MagalE

MuirD

ManthorpeM

VaronS

1992 CG-4, a new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type-2 astrocytes. J Neurosci Res 31 193 204

30. EbersoleTA

ChenQ

JusticeMJ

ArtztK

1996 The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nat Genet 12 260 265

31. LiZ

TakakuraN

OikeY

ImanakaT

ArakiK

2003 Defective smooth muscle development in qkI-deficient mice. Dev Growth Differ 45 449 462

32. VasudevanS

SteitzJA

2007 AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell 128 1105 1118

33. WangE

DimovaN

CambiF

2007 PLP/DM20 ratio is regulated by hnRNPH and F and a novel G-rich enhancer in oligodendrocytes. Nucleic Acids Res 35 4164 4178

34. WangE

HuangZ

HobsonGM

DimovaN

SperleK

2006 PLP1 alternative splicing in differentiating oligodendrocytes: characterization of an exonic splicing enhancer. J Cell Biochem 97 999 1016

35. MiliS

SteitzJA

2004 Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses. Rna 10 1692 1694

36. HutchisonS

LeBelC

BlanchetteM

ChabotB

2002 Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5′ splice site selection in the hnRNP A1 mRNA precursor. J Biol Chem 277 29745 29752

37. AguirreA

DupreeJL

ManginJM

GalloV

2007 A functional role for EGFR signaling in myelination and remyelination. Nat Neurosci 10 990 1002

38. CuiQL

FogleE

AlmazanG

2006 Muscarinic acetylcholine receptors mediate oligodendrocyte progenitor survival through Src-like tyrosine kinases and PI3K/Akt pathways. Neurochem Int 48 383 393

39. GordonD

KiddGJ

SmithR

2008 Antisense suppression of tau in cultured rat oligodendrocytes inhibits process formation. J Neurosci Res 86 2591 2601

40. MayedaA

KrainerAR

1992 Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68 365 375

41. CaceresJF

StammS

HelfmanDM

KrainerAR

1994 Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 265 1706 1709

42. YangX

BaniMR

LuSJ

RowanS

Ben-DavidY

1994 The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5′ splice site selection in vivo. Proc Natl Acad Sci U S A 91 6924 6928

43. BurdCG

DreyfussG

1994 RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. Embo J 13 1197 1204

44. HanK

YeoG

AnP

BurgeCB

GrabowskiPJ

2005 A combinatorial code for splicing silencing: UAGG and GGGG motifs. PLoS Biol 3 e158 doi:10.1371/journal.pbio.0030158

45. EmigD

SalomonisN

BaumbachJ

LengauerT

ConklinBR

2010 AltAnalyze and DomainGraph: analyzing and visualizing exon expression data. Nucleic Acids Res 38 Suppl W755 762

46. WangZ

RolishME

YeoG

TungV

MawsonM

2004 Systematic identification and analysis of exonic splicing silencers. Cell 119 831 845

47. ZhangY

LuZ

KuL

ChenY

WangH

2003 Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism. Embo J 22 1801 1810

48. UmemoriH

KadowakiY

HirosawaK

YoshidaY

HironakaK

1999 Stimulation of myelin basic protein gene transcription by Fyn tyrosine kinase for myelination. J Neurosci 19 1393 1397

49. ZhangQS

MancheL

XuRM

KrainerAR

2006 hnRNP A1 associates with telomere ends and stimulates telomerase activity. Rna 12 1116 1128

50. GuilS

CaceresJF

2007 The multifunctional RNA-binding protein hnRNP A1 is required for processing fo miR-18a. Nature Structural and Molecular Biology 14 591 596

51. MichlewskiG

GuilS

SempleCA

CaceresJF

2008 Posttranscriptional regulation of miRNAs harboring conserved terminal loops. Mol Cell 32 383 393

52. DsouzaM

LarsenN

OverbeekR

1997 Searching for patterns in genomic data. Trends Genet 13 497 498

53. UleJ

JensenKB

RuggiuM

MeleA

UleA

2003 CLIP identifies Nova-regulated RNA networks in the brain. Science 302 1212 1215

54. UleJ

JensenK

MeleA

DarnellRB

2005 CLIP: a method for identifying protein-RNA interaction sites in living cells. Methods 37 376 386

55. LicatalosiDD

MeleA

FakJJ

UleJ

KayikciM

2008 HITS-CLIP yields genome-wide insights into brain alternative RNA processing. Nature 456 464 469

56. JensenKB

DarnellRB

2008 CLIP: crosslinking and immunoprecipitation of in vivo RNA targets of RNA-binding proteins. Methods Mol Biol 488 85 98

57. AllenNC

BagadeS

McQueenMB

IoannidisJP

KavvouraFK

2008 Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40 827 834

58. AtzME

RollinsB

VawterMP

2007 NCAM1 association study of bipolar disorder and schizophrenia: polymorphisms and alternatively spliced isoforms lead to similarities and differences. Psychiatr Genet 17 55 67

59. InoueK

OsakaH

SugiyamaN

KawanishiC

OnishiH

1996 A duplicated PLP gene causing Pelizaeus-Merzbacher disease detected by comparative multiplex PCR. Am J Hum Genet 59 32 39

60. StefanssonH

RujescuD

CichonS

PietilainenOP

IngasonA

2008 Large recurrent microdeletions associated with schizophrenia. Nature 455 232 236

61. McCarthySE

MakarovV

KirovG

AddingtonAM

McClellanJ

2009 Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet 41 1223 1227

62. ZhangF

SeemanP

LiuP

WetermanMA

Gonzaga-JaureguiC

2010 Mechanisms for nonrecurrent genomic rearrangements associated with CMT1A or HNPP: rare CNVs as a cause for missing heritability. Am J Hum Genet 86 892 903

63. ShanerNC

CampbellRE

SteinbachPA

GiepmansBN

PalmerAE

2004 Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 22 1567 1572

64. PaganoJM

FarleyBM

McCoigLM

RyderSP

2007 Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5. J Biol Chem 282 8883 8894

65. TenenbaumSA

LagerPJ

CarsonCC

KeeneJD

2002 Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays. Methods 26 191 198

66. Chen-PlotkinAS

Sadri-VakiliG

YohrlingGJ

BravemanMW

BennCL

2006 Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease. Neurobiol Dis 22 233 241

67. RutledgeRG

2004 Sigmoidal curve-fitting redefines quantitative real-time PCR with the prospective of developing automated high-throughput applications. Nucleic Acids Res 32 e178