Determinative Developmental Cell Lineages Are Robust to Cell Deaths

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It is widely believed that development plays an important role in the phenotypic robustness of organisms to environmental and genetic perturbations. But, the developmental process and cell fate are largely predetermined and fixed in some species, including for example mollusks, annelids, tunicates, and nematodes. How these organisms deal with perturbations that cause cell deaths in ontogenesis has been a long-standing puzzle. We propose and demonstrate that the developmental cell lineages of these species are structured such that the resulting cellular compositions of the organisms are only moderately affected by cell deaths. A series of highly nonrandom features of the cell lineages underlie their developmental robustness and these features likely originated as adaptations in the face of various disturbances during development. Our findings reveal important organizing principles of determinative developmental cell lineages and a conceptually new mechanism of phenotypic robustness, which have broad implications for development and evolution.

Vyšlo v časopise: Determinative Developmental Cell Lineages Are Robust to Cell Deaths. PLoS Genet 10(7): e32767. doi:10.1371/journal.pgen.1004501
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004501

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