The PTK7-Related Transmembrane Proteins Off-track and Off-track 2 Are Co-receptors for Wnt2 Required for Male Fertility

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Wnts are secreted, growth factor-like proteins that are important for the development of many tissues and organs in animals. They are also required in adult animals and humans for controlling the balance between growth and differentiation. Wnts are bound at the cell surface by Wnt receptors, which are dimers composed of a Frizzled protein and a co-receptor. Here we have analyzed the Drosophila Wnt co-receptors Off-track (Otk) and Off-track 2 (Otk2), which are closely related to vertebrate Protein tyrosine kinase 7 (PTK7). We found that in contrast to PTK7 in mice and frogs, which controls planar cell polarity (PCP), Otk and Otk2 together are needed in males for development of the ejaculatory duct, a tube-like organ that transports the mature sperm. Our data furthermore indicate that Otk and Otk2 are co-receptors for Wnt2. The sterile phenotype of Wnt2 mutant males is not identical to that of otk, otk2 double mutants, so additional Wnts may be involved in this process. Interestingly, the function of Wnt2 in male fertility appears to be evolutionarily conserved, because male mice mutant for Wnt7A, the vertebrate homolog of Drosophila Wnt2, are sterile due to abnormal development of the vas deferens, which corresponds to the fly ejaculatory duct.

Vyšlo v časopise: The PTK7-Related Transmembrane Proteins Off-track and Off-track 2 Are Co-receptors for Wnt2 Required for Male Fertility. PLoS Genet 10(7): e32767. doi:10.1371/journal.pgen.1004443
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004443

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