The Nesprin Family Member ANC-1 Regulates Synapse Formation and Axon Termination by Functioning in a Pathway with RPM-1 and β-Catenin

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The molecular mechanisms that underpin synapse formation and axon termination are central to forming a functional, fully connected nervous system. The PHR proteins are important regulators of neuronal development that function in axon outgrowth and termination, as well as synapse formation. Here we describe the discovery of a novel, conserved pathway that is positively regulated by the C. elegans PHR protein, RPM-1. This pathway is composed of RPM-1, ANC-1 (a Nesprin family protein), and BAR-1 (a canonical β-catenin). Nesprins, such as ANC-1, regulate nuclear anchorage and positioning in multinuclear cells. We now show that in neurons, ANC-1 regulates neuronal development by positively regulating BAR-1. Thus, Nesprins are multi-functional proteins that act through β-catenin to regulate neuronal development, and link the nucleus to the actin cytoskeleton in order to mediate nuclear anchorage and positioning in multi-nuclear cells.

Vyšlo v časopise: The Nesprin Family Member ANC-1 Regulates Synapse Formation and Axon Termination by Functioning in a Pathway with RPM-1 and β-Catenin. PLoS Genet 10(7): e32767. doi:10.1371/journal.pgen.1004481
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004481

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