Canine Spontaneous Head and Neck Squamous Cell Carcinomas Represent Their Human Counterparts at the Molecular Level

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Head and neck squamous cell carcinoma (HNSCC) represents the sixth leading cancer by incidence in humans; thus, developing effective therapeutic interventions is important. Although great advance has been made in our understanding of the biology of HNSCC over the past several decades, translating the research findings into clinical success has been frustratingly slow, and anticancer drug development remains a lengthy and expensive process. A significant challenge is that drug effects in current preclinical cancer models often do not predict clinical results, and there lacks translational models that can bridge the gap between preclinical research and human clinical trials. Here we report a pilot study that represents the first genome-wide characterization of spontaneously occurring HNSCCs in pet dogs. The study reveals a strong dog-human molecular homology at various levels, indicating the likelihood that spontaneous canine HNSCC molecularly represents its human counterpart. If conclusions of this pilot study are validated with a large sample size and more efforts are put into building better resource and infrastructure for canine cancer research, spontaneous canine HNSCCs could effectively serve as a much-needed translational model that bridges the gap between preclinical research and human trials.

Vyšlo v časopise: Canine Spontaneous Head and Neck Squamous Cell Carcinomas Represent Their Human Counterparts at the Molecular Level. PLoS Genet 11(6): e32767. doi:10.1371/journal.pgen.1005277
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005277

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