Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins

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A main function of the hormone insulin in the body is to regulate metabolism of glucose. The hormone causes body cells in different organs and tissues to utilize glucose from the bloodstream, storing the excess amount. Insulin resistance which reflects the inability of insulin to properly regulate glucose metabolism is common in people with obesity and/or type 2 diabetes. This insulin resistance is strongly associated with cardiovascular disease and increases the risk of death. However, the reasons that account for this insulin resistance phenomenon are currently not well understood. Here, we show that Bardet Biedl Syndrome proteins are required for proper action of insulin. We found that cells or animals that are deficient in Bardet Biedl Syndrome proteins are unable to respond to insulin. These results provide an explanation why patients that carry mutations in the Bardet Biedl Syndrome genes are insulin resistant, and will potentially contribute to understand common human forms of insulin resistance.

Vyšlo v časopise: Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins. PLoS Genet 11(6): e32767. doi:10.1371/journal.pgen.1005311
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005311

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