Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake

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In multicellular animals, nutrients and metabolites required for cell growth are distributed throughout the body by the blood circulation or in insects, by hemolymph. The uptake of these molecules by cells is tightly controlled to ensure the necessary coordination between cellular requirements and organismal homeostasis. Here we examine the mechanisms that mediate the cellular uptake of lipids in Drosophila melanogaster, a model organisms increasingly used in studies of metabolic homeostasis and its intersection with growth, aging and disease. In Drosophila, the majority of hemolymph lipids are carried in a lipoprotein particle named lipophorin. Lipid uptake in organs such as the ovaries or the imaginal discs is initiated by the expression of receptors of the LDLR family in the cell membrane. We show that these receptors bind with high affinity to a circulating lipoprotein named LTP, recruiting it to the cell surface. Surprisingly, LTP is not a major lipid carrier but instead catalyzes the transfer of lipids from lipophorin to cells. Our results improve our understanding of a central aspect of lipid metabolism in Drosophila and illustrate that although homologous proteins of the LDLR family play central roles in lipid uptake across phyla, the specific molecular mechanisms involved are diverse.

Vyšlo v časopise: Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake. PLoS Genet 11(6): e32767. doi:10.1371/journal.pgen.1005356
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005356

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