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is an Unstable Pathogen
Showing Evidence of Significant Genomic Flux


Citrobacter rodentium is a natural mouse pathogen that causes

attaching and effacing (A/E) lesions. It shares a common virulence strategy with

the clinically significant human A/E pathogens enteropathogenic E.

coli
(EPEC) and enterohaemorrhagic E. coli (EHEC)

and is widely used to model this route of pathogenesis. We previously reported

the complete genome sequence of C. rodentium ICC168, where we

found that the genome displayed many characteristics of a newly evolved

pathogen. In this study, through PFGE, sequencing of isolates showing variation,

whole genome transcriptome analysis and examination of the mobile genetic

elements, we found that, consistent with our previous hypothesis, the genome of

C. rodentium is unstable as a result of repeat-mediated,

large-scale genome recombination and because of active transposition of mobile

genetic elements such as the prophages. We sequenced an additional C.

rodentium
strain, EX-33, to reveal that the reference strain ICC168

is representative of the species and that most of the inactivating mutations

were common to both isolates and likely to have occurred early on in the

evolution of this pathogen. We draw parallels with the evolution of other

bacterial pathogens and conclude that C. rodentium is a

recently evolved pathogen that may have emerged alongside the development of

inbred mice as a model for human disease.


Vyšlo v časopise: is an Unstable Pathogen Showing Evidence of Significant Genomic Flux. PLoS Pathog 7(4): e32767. doi:10.1371/journal.ppat.1002018
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1002018

Souhrn

Citrobacter rodentium is a natural mouse pathogen that causes

attaching and effacing (A/E) lesions. It shares a common virulence strategy with

the clinically significant human A/E pathogens enteropathogenic E.

coli
(EPEC) and enterohaemorrhagic E. coli (EHEC)

and is widely used to model this route of pathogenesis. We previously reported

the complete genome sequence of C. rodentium ICC168, where we

found that the genome displayed many characteristics of a newly evolved

pathogen. In this study, through PFGE, sequencing of isolates showing variation,

whole genome transcriptome analysis and examination of the mobile genetic

elements, we found that, consistent with our previous hypothesis, the genome of

C. rodentium is unstable as a result of repeat-mediated,

large-scale genome recombination and because of active transposition of mobile

genetic elements such as the prophages. We sequenced an additional C.

rodentium
strain, EX-33, to reveal that the reference strain ICC168

is representative of the species and that most of the inactivating mutations

were common to both isolates and likely to have occurred early on in the

evolution of this pathogen. We draw parallels with the evolution of other

bacterial pathogens and conclude that C. rodentium is a

recently evolved pathogen that may have emerged alongside the development of

inbred mice as a model for human disease.


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Štítky
Hygiena a epidemiológia Infekčné lekárstvo Laboratórium

Článok vyšiel v časopise

PLOS Pathogens


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