The MARCH Family E3 Ubiquitin Ligase K5 Alters Monocyte Metabolism and Proliferation through Receptor Tyrosine Kinase Modulation

1. GatenbyRA

GilliesRJ

2004 Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4 891 899

2. DeBerardinisRJ

ChengT

2010 Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 29 313 324

3. KoukourakisMI

GiatromanolakiA

HarrisAL

SivridisE

2006 Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res 66 632 637

4. CesarmanE

ChangY

MoorePS

SaidJW

KnowlesDM

1995 Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332 1186 1191

5. ChangY

CesarmanE

PessinMS

LeeF

CulpepperJ

1994 Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266 1865 1869

6. SoulierJ

GrolletL

OksenhendlerE

CacoubP

Cazals-HatemD

1995 Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86 1276 1280

7. ValentiR

HuberV

IeroM

FilipazziP

ParmianiG

2007 Tumor-released microvesicles as vehicles of immunosuppression. Cancer Res 67 2912 2915

8. SolinasG

GermanoG

MantovaniA

AllavenaP

2009 Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 86 1065 1073

9. CoffeltSB

HughesR

LewisCE

2009 Tumor-associated macrophages: effectors of angiogenesis and tumor progression. Biochim Biophys Acta 1796 11 18

10. GasperiniP

SakakibaraS

TosatoG

2008 Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis. J Leukoc Biol 84 994 1000

11. ChoiYB

NicholasJ

2008 Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines. J Virol 82 6501 6513

12. LiuC

OkruzhnovY

LiH

NicholasJ

2001 Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects. J Virol 75 10933 10940

13. KangT

YeFC

GaoSJ

WangLD

2008 Angiogenesis, Kaposi's Sarcoma and Kaposi's Sarcoma-Associated Herpesvirus. Virol Sin 23 449 458

14. ChungYH

MeansRE

ChoiJK

LeeBS

JungJU

2002 Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein activates myeloid-lineage cells to induce inflammatory cytokine production. J Virol 76 4688 4698

15. SalataC

CurtarelloM

CalistriA

SartoriE

SetteP

2009 vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity. J Cell Physiol 219 698 706

16. QinZ

KearneyP

PlaisanceK

ParsonsCH

2010 Pivotal advance: Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes. J Leukoc Biol 87 25 34

17. WestJ

DamaniaB

2008 Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection. J Virol 82 5440 5449

18. RappoccioloG

JenkinsFJ

HenslerHR

PiazzaP

JaisM

2006 DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages. J Immunol 176 1741 1749

19. RappoccioloG

HenslerHR

JaisM

ReinhartTA

PeguA

2008 Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN. J Virol 82 4793 4806

20. KerurN

VeettilMV

Sharma-WaliaN

SadagopanS

BotteroV

2010 Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signaling. Virology 406 103 116

21. WenKW

DamaniaB

2010 Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis. Cancer Lett 289 140 150

22. MontanerS

SodhiA

MolinoloA

BuggeTH

SawaiET

2003 Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 3 23 36

23. MutluAD

CavallinLE

VincentL

ChiozziniC

ErolesP

2007 In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell 11 245 258

24. DittmerD

LagunoffM

RenneR

StaskusK

HaaseA

1998 A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J Virol 72 8309 8315

25. KrishnanHH

NaranattPP

SmithMS

ZengL

BloomerC

2004 Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78 3601 3620

26. NathanJA

LehnerPJ

2009 The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases. Exp Cell Res 315 1593 1600

27. ChangH

DittmerDP

ShinYC

ChulSY

HongY

2005 Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expression. J Virol 79 14371 14382

28. ChangH

2006 Notch signal transduction induces a novel profile of Kaposi's sarcoma-associated herpesvirus gene expression. J Microbiol 44 217 225

29. GŸntherT

GrundhoffA

2010 The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog 6 e1000935

30. HaqueM

UedaK

NakanoK

HirataY

ParraviciniC

2001 Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. J Gen Virol 82 1175 1180

31. MeansRE

LangSM

JungJU

2007 The Kaposi's sarcoma-associated herpesvirus K5 E3 ubiquitin ligase modulates targets by multiple molecular mechanisms. J Virol 81 6573 6583

32. ZhivotovskyB

OrreniusS

2009 The Warburg Effect returns to the cancer stage. Semin Cancer Biol 19 1 3

33. LagunoffM

BechtelJ

VenetsanakosE

RoyAM

AbbeyN

2002 De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J Virol 76 2440 2448

34. AnFQ

FolarinHM

CompitelloN

RothJ

GersonSL

2006 Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. J Virol 80 4833 4846

35. DelgadoT

CarrollPA

PunjabiAS

MargineantuD

HockenberyDM

2010 Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells. Proc Natl Acad Sci U S A 107 10696 10701

36. ElstromRL

BauerDE

BuzzaiM

KarnauskasR

HarrisMH

2004 Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64 3892 3899

37. HitosugiT

KangS

Vander HeidenMG

ChungTW

ElfS

2009 Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal 2 ra73

38. DangCV

2009 PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect. Sci Signal 2 pe75

39. BartronsR

CaroJ

2007 Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr 39 223 229

40. Brahimi-HornMC

ChicheJ

PouysségurJ

2007 Hypoxia signalling controls metabolic demand. Curr Opin Cell Biol 19 223 229

41. LuH

ForbesRA

VermaA

2002 Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 277 23111 23115

42. PoreN

JiangZ

ShuHK

BernhardE

KaoGD

2006 Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. Mol Cancer Res 4 471 479

43. ZundelW

SchindlerC

Haas-KoganD

KoongA

KaperF

2000 Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14 391 396

44. PoreN

LiuS

Haas-KoganDA

O'RourkeDM

MaityA

2003 PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. Cancer Res 63 236 241

45. ZhangH

GaoP

FukudaR

KumarG

KrishnamacharyB

2007 HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11 407 420

46. SandauKB

FausHG

BrüneB

2000 Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem Biophys Res Commun 278 263 267

47. ZhongH

ChilesK

FeldserD

LaughnerE

HanrahanC

2000 Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60 1541 1545

48. RobeyIF

StephenRM

BrownKS

BaggettBK

GatenbyRA

2008 Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia 10 745 756

49. PenumathsaSV

ThirunavukkarasuM

ZhanL

MaulikG

MenonVP

2008 Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. J Cell Mol Med 12 2350 2361

50. LuoJ

ManningBD

CantleyLC

2003 Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4 257 262

51. MaciaE

EhrlichM

MassolR

BoucrotE

BrunnerC

2006 Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell 10 839 850

52. KirchhausenT

MaciaE

PelishHE

2008 Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol 438 77 93

53. WangL

DamaniaB

2008 Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Cancer Res 68 4640 4648

54. CarrollPA

KenersonHL

YeungRS

LagunoffM

2006 Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol 80 10802 10812

55. WeihuaZ

TsanR

HuangWC

WuQ

ChiuCH

2008 Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 13 385 393

56. DittmerDP

KrownSE

2007 Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus. Curr Opin Oncol 19 452 457

57. IkezoeT

NishiokaC

TasakaT

YangY

KomatsuN

2006 The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling. Mol Cancer Ther 5 2522 2530

58. Gutiérrez-DalmauA

Sánchez-FructuosoA

Sanz-GuajardoA

MazuecosA

FrancoA

2005 Efficacy of conversion to sirolimus in posttransplantation Kaposi's sarcoma. Transplant Proc 37 3836 3838

59. StalloneG

InfanteB

GrandalianoG

SchenaFP

GesualdoL

2008 Kaposi's sarcoma and mTOR: a crossroad between viral infection neoangiogenesis and immunosuppression. Transpl Int 21 825 832

60. StalloneG

InfanteB

PontrelliP

RanieriE

LoverreA

2009 ID2-VEGF-related pathways in the pathogenesis of Kaposi's sarcoma: a link disrupted by rapamycin. Am J Transplant 9 558 566

61. LebbéC

EuvrardS

BarrouB

Pouteil-NobleC

GarnierJL

2006 Sirolimus conversion for patients with posttransplant Kaposi's sarcoma. Am J Transplant 6 2164 2168

62. MurphyJE

PadillaBE

HasdemirB

CottrellGS

BunnettNW

2009 Endosomes: a legitimate platform for the signaling train. Proc Natl Acad Sci U S A 106 17615 17622

63. MoniniP

ColombiniS

StürzlM

GolettiD

CafaroA

1999 Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma. Blood 93 4044 4058

64. BlasigC

ZietzC

HaarB

NeipelF

EsserS

1997 Monocytes in Kaposi's sarcoma lesions are productively infected by human herpesvirus 8. J Virol 71 7963 7968

65. JonesKD

AokiY

ChangY

MoorePS

YarchoanR

1999 Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells. Blood 94 2871 2879

66. AokiY

YarchoanR

BraunJ

IwamotoA

TosatoG

2000 Viral and cellular cytokines in AIDS-related malignant lymphomatous effusions. Blood 96 1599 1601