Microbial Pathogens Trigger Host DNA Double-Strand Breaks Whose Abundance Is Reduced by Plant Defense Responses

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Multicellular organisms are continuously exposed to microbes and have developed sophisticated defense mechanisms to counter attack by microbial pathogens. Organisms also encounter many types of DNA damage and have evolved multiple mechanisms to maintain their genomic integrity. Even though these two fundamental responses have been characterized extensively, the relationship between them remains largely unclear. Our study demonstrates that microbial plant pathogens with diverse life styles, including bacteria, oomycete and fungal pathogens, induce double-strand breaks (DSBs) in the genomes of infected host plant cells. DSB induction is apparently a common feature during plant-pathogen interactions. DSBs are the most deleterious form of DNA damage and can lead to chromosomal aberrations and gene mutations. In response to pathogen infection, plant immune responses are activated and contribute to suppressing pathogen-induced DSBs, thereby maintaining better genome integrity and stability. The findings identify important ways that the plant immune and DNA damage repair responses are interconnected. Awareness of the above phenomena may foster future development of disease management approaches that improve crop productivity under biotic stress.

Vyšlo v časopise: Microbial Pathogens Trigger Host DNA Double-Strand Breaks Whose Abundance Is Reduced by Plant Defense Responses. PLoS Pathog 10(4): e32767. doi:10.1371/journal.ppat.1004030
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004030

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