TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8 T Cells in Rhesus Monkeys

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MHC-restricted CD8+ T cell populations that bind viral proteins are often present at different frequencies. It is thought that those virus-specific CD8+ T cells that are present at the highest frequency are predominantly responsible for eliciting control of viral infections. While the number of virus-specific CD8+ T cells is undoubtedly important, the functionality of these cells may also play an anti-viral role. It is not known if high-frequency virus-specific CD8+ T cells are more functionally effective against viral infection than those present at low frequencies. In this study, we characterized the functional differences between the SIV-specific cells present at high versus low frequencies in rhesus monkeys infected with simian immunodeficiency virus (SIV). We found that the high- and low-frequency SIV-specific cells had different functional capacities during acute and chronic SIV infection. We also found that the affinity with which a cell interacts with viral proteins may contribute to these functional differences. These findings further our understanding of anti-viral immune responses and may help to inform HIV vaccine development.

Vyšlo v časopise: TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8 T Cells in Rhesus Monkeys. PLoS Pathog 10(4): e32767. doi:10.1371/journal.ppat.1004069
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004069

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