Mechanisms of Drug Resistance and Cancer Stem Cells

Česká verzia

Authors: J. Holčáková; M. Nekulová; P. Orzol; B. Vojtěšek
Authors place of work: Regionální centrum aplikované molekulární onkologie, Masarykův onkologický ústav, Brno
Published in the journal: Klin Onkol 2014; 27(Supplementum): 34-41

Summary

Although the success of anticancer treatments has been increasing annually, drug resistance remains the dominant cause of death of cancer patients. Initial therapy often leaves residual disease that leads to repeated tumor development or to loss of its sensitivity to available therapy. One reason of residual disease formation is the presence of cancer stem cells (CSCs). CSCs have been identified as a small population of cells that is capable of self‑ renewal and differentiation. It is supposed that these cells are responsible for cancer initiation, progression, metastasis, recurrence and drug resistance. Over the past years, much attention has been paid to development of CSCs‑related therapies and to identification of key molecules involved in controlling the specific properties of CSCs populations. This article reviews the basic mechanisms of drug resistance in relation to cancer stem cells.

Key words:
drug resistance − cancer stem cells − membrane transport proteins – epithelial-mesenchymal transition – tumor microenvironment − apoptosis

This work was supported by research program of the Internal Grant Agency, Ministry of Health of the Czech Republic: NT/14602 – 3/2013, by the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO CZ.1.05/2.1.00/03.0101) and by Ministry of Health, Czech Republic − conceptual development of research organization (MMCI, 00209805).

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
3. 2. 2014

Accepted:
7. 5. 2014

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