DNA Repair Pathway Selection Caused by Defects in , , and Telomere Addition Generates Specific Chromosomal Rearrangement Signatures

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Recent advances in the sequencing of human cancer genomes have revealed that some types of genome rearrangements are more common in specific types of cancers. Thus, these cancers may share defects in DNA repair mechanisms, which may play roles in initiation or progression of the disease and may be useful therapeutically. Linking a common rearrangement signature to a specific genetic or epigenetic alteration is currently challenging, because we do not know which rearrangement signatures are linked to which DNA repair defects. Here we used a genetic assay in the model organism Saccharomyces cerevisiae to specifically link two classes of chromosomal rearrangements, interstitial deletions and inverted duplications, to specific genetic defects. These results begin to map out the links between observed chromosomal rearrangements and specific DNA repair defects and in the present case, may provide insights into the chromosomal rearrangements frequently observed in metastatic pancreatic cancer.

Vyšlo v časopise: DNA Repair Pathway Selection Caused by Defects in , , and Telomere Addition Generates Specific Chromosomal Rearrangement Signatures. PLoS Genet 10(4): e32767. doi:10.1371/journal.pgen.1004277
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004277

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