Widespread Use of Non-productive Alternative Splice Sites in

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Accurate gene expression requires the transfer of gene information from DNA to RNA. When DNA is transcribed into RNA, part of the RNA needs to be removed (spliced) to generate a proper copy of the genetic information. This process needs to be very accurate to preserve the genetic information that will be transferred into proteins. Our study shows that in baker's yeast, the splicing process does not always produce the correctly spliced products, as RNA splicing events frequently utilize incorrect splice sites. However, these deficient RNA molecules are eliminated from cells by a quality control mechanism to preserve the integrity of the genetic information. However, incorrect splicing is not useless, as it can be used to regulate the quantity of RNA that is generated.

Vyšlo v časopise: Widespread Use of Non-productive Alternative Splice Sites in. PLoS Genet 10(4): e32767. doi:10.1371/journal.pgen.1004249
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004249

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