Fine Mapping of Dominant -Linked Incompatibility Alleles in Hybrids

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The inviability or sterility of interspecific hybrids is one of the mechanisms of reproductive isolation that keep species apart. In this report, we use the genetic tools of Drosophila melanogaster to assess the cytological locations and relative frequency of dominant X-linked alleles involved in hybrid inviability in three different interspecific crosses. We map the genomic regions of the D. melanogaster X-chromosome that cause inviability in hybrids produced by D. melanogaster females crossed to males of three other Drosophila species: D. simulans, D. mauritiana and D. santomea. For each hybrid inviability allele we identified, we characterized the developmental defects that occur in the inviable hybrids. Our results show that the effect of these X-linked lethal regions is lineage-specific, as is the total number of alleles that cause hybrid inviability. These results can be expanded and will allow for the exact identification of X-linked D. melanogaster alleles in these three different hybrid contexts.

Vyšlo v časopise: Fine Mapping of Dominant -Linked Incompatibility Alleles in Hybrids. PLoS Genet 10(4): e32767. doi:10.1371/journal.pgen.1004270
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004270

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