Recombination Accelerates Adaptation on a Large-Scale Empirical Fitness Landscape in HIV-1

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One of the most challenging issues in evolutionary biology concerns the question of why most organisms exchange genetic material with each other, e.g. during sexual reproduction. Gene shuffling can create genetic diversity that facilitates adaptation to new environments, but theory shows that this effect is highly dependent on how different genes interact in determining the fitness of an organism. Using a large data set of fitness values based on HIV-1, we provide evidence that shuffling of genetic material indeed raises the level of genetic diversity, and as a result accelerates adaptation. Our results also propose genetic shuffling as a mechanism utilized by HIV to accelerate the evolution of multi-drug-resistant strains.

Vyšlo v časopise: Recombination Accelerates Adaptation on a Large-Scale Empirical Fitness Landscape in HIV-1. PLoS Genet 10(6): e32767. doi:10.1371/journal.pgen.1004439
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004439

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