The MAP Kinase p38 Is Part of Circadian Clock

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The circadian and the stress system are two distinct physiological systems that help the organism to adapt to environmental challenges. While the latter elicits reactive responses to acute environmental changes, the circadian system predicts daily occurring alterations and prepares the organism in advance. However, these two responses are not mutually exclusive. Studies in the last years prove a strong interaction between both systems showing a strong time-related stress response depending on the time of day of stressor presentation on the one hand and increased disturbances of daily rhythms, like sleep disorders, in consequence of uncontrolled or excessive stress on the other. Here, we show that the mitogen-activated protein kinase p38, a well characterized component of immune and stress signaling pathways is simultaneously a part of the core circadian clock in Drosophila melanogaster. Our results demonstrate that p38 is activated in a circadian manner and that under constant darkness normal p38 signaling is necessary for the maintenance of 24 h rhythms on the behavioral and molecular level. Together, this strongly indicates a role of p38 in the core clock and further suggests that it is a possible nodal point between the circadian and the stress system.

Vyšlo v časopise: The MAP Kinase p38 Is Part of Circadian Clock. PLoS Genet 10(8): e32767. doi:10.1371/journal.pgen.1004565
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004565

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