Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Oocytes
In acentrosomal oocytes, spindle assembly depends on the chromosomes. The nature of the chromosome-microtubule interactions in oocytes that organize spindle bipolarity and orientation of the homologs has been unclear. We have found that several types of functional chromosome-microtubule interactions exist in oocytes, and that each type participates in unique aspects of chromosome orientation and spindle assembly. We present here a model for chromosome-based spindle assembly and chromosome movements in oocytes that highlights the multiple and unappreciated roles played by the kinetochores and has implications for how homologous chromosomes bi-orient during meiosis.
Vyšlo v časopise:
Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Oocytes. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005605
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pgen.1005605
Souhrn
In acentrosomal oocytes, spindle assembly depends on the chromosomes. The nature of the chromosome-microtubule interactions in oocytes that organize spindle bipolarity and orientation of the homologs has been unclear. We have found that several types of functional chromosome-microtubule interactions exist in oocytes, and that each type participates in unique aspects of chromosome orientation and spindle assembly. We present here a model for chromosome-based spindle assembly and chromosome movements in oocytes that highlights the multiple and unappreciated roles played by the kinetochores and has implications for how homologous chromosomes bi-orient during meiosis.
Zdroje
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Genetika Reprodukčná medicínaČlánok vyšiel v časopise
PLOS Genetics
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