Axon Regeneration Is Regulated by Ets–C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca Signaling Pathways

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An axon’s ability to regenerate after injury is governed by cell-intrinsic regeneration pathways. In C. elegans, the JNK and p38 MAPK pathways play an important role in axon regeneration. The JNK pathway is activated by growth factor SVH-1, which signals through its receptor SVH-2. It is known that expression of the svh-2 gene is induced in response to axonal injury, however the molecular mechanisms underlying this induction have been unknown. Here, we demonstrate that induction of svh-2 expression in response to axon injury involves the transcription factors ETS-4 and CEBP-1, which function downstream of the cAMP and Ca2+–p38 MAPK pathways, respectively. Our results suggest that these two injury-signaling pathways converge to regulate expression of the svh-2 gene and thereby promote axon regeneration.

Vyšlo v časopise: Axon Regeneration Is Regulated by Ets–C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca Signaling Pathways. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005603
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005603

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