Pelle Modulates dFoxO-Mediated Cell Death in

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In the present study we report a Toll pathway independent function of Pll in modulating apoptotic cell death. Our major findings include: 1) loss of pll generates Toll pathway-independent wing phenotypes, which are caused by a reduction in cell number but not cell size; 2) depletion of pll up-regulates the transcription of pro-apoptotic genes hid, reaper and grim, and triggers caspase-mediated cell death, whereas cell proliferation remains unaffected; 3) pll modulates caspase activation and cell death through the transcription factor dFoxO; 4) loss of pll promotes dFoxO translocation from cytoplasm to nucleus, and activates the transcription of dFoxO target gene Thor/4E-BP; 5) Pll physically interacts with dFoxO and phosphorylates dFoxO directly. Thus, this work characterizes a previously unknown physiological function of pll that is independent of the Toll pathway.

Vyšlo v časopise: Pelle Modulates dFoxO-Mediated Cell Death in. PLoS Genet 11(10): e32767. doi:10.1371/journal.pgen.1005589
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005589

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