Matrix Metalloproteinase 2 Is Required for Ovulation and Corpus Luteum Formation in

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Sexual reproduction is thought to be a highly divergent process due to fast evolution and speciation. For example, sperm from one species can seldom fertilize eggs from another species, indicating that different molecular machinery for fertilization is applied in different species. In contrast to this divergent view, ovulation, the process of liberating mature eggs from the ovary, is a general phenomenon throughout the Metazoa. We provide evidence that basic mechanisms of ovulation are conserved. Like mammalian follicles, Drosophila follicles consist of single oocytes surrounded by a layer of follicle cells. Drosophila follicles degrade their posterior follicle cells to allow the oocyte to rupture into the oviduct during ovulation. The residual postovulatory follicles reside in the ovary, accumulate yellowish pigmentation, and produce the steroid hormone ecdysone, features which resemble the mammalian corpus luteum. We also showed that matrix metalloproteinase, a type of proteinase proposed to degrade the mammalian follicle wall during ovulation, is required in Drosophila for posterior follicle cell degradation and ovulation. These findings are particularly important because this simple genetic model system will speed up the identification of many conserved regulators required for regulating matrix metalloproteinase activity and ovulation in human, processes that influence ovarian cancer formation and cancer metastasis.

Vyšlo v časopise: Matrix Metalloproteinase 2 Is Required for Ovulation and Corpus Luteum Formation in. PLoS Genet 11(2): e32767. doi:10.1371/journal.pgen.1004989
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004989

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