Identification of as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles

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Hair, feather, and scale patterns are a universal feature of vertebrate surface morphology. These patterns are under precise genetic control as seen by their species-specificity and by their alterations in different breeds of domesticated animals. The first clues to the mechanism of hair patterning in mammals came from genetic analyses of proteins that are homologous to a small set of Drosophila proteins that control patterning of bristles and hairs on the insect body surface and wings. The patterning process, referred to as planar cell polarity, involves a cell surface protein, Frizzled6, which is produced in skin and hair follicles. Following a chance observation that some Frizzled6 mutant mice exhibit an unusual hair pattern in which all of the hair follicles on the posterior half of the back have reversed orientations, we have identified a single spontaneous mutation that accounts for this reversal. The mutation removes a single coding exon from the gene coding for the membrane protein Astrotactin2. Interestingly, a closely related protein, Astrotactin1, has been implicated in directed neuronal migration along a glial substrate, suggesting a mechanistic connection between patterning mechanisms in skin and brain.

Vyšlo v časopise: Identification of as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles. PLoS Genet 11(9): e32767. doi:10.1371/journal.pgen.1005532
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005532

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