The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene during Male Meiosis in

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Meiosis is a critical event in sexual reproduction. During meiosis, chromosomes recombine and segregate twice consecutively to produce haploid daughter cells, which differentiate into gametes. In humans, errors in meiosis are the leading causes of congenital birth defects. In plants, bypassing the meiotic program can lead to production of clonal seeds that retain hybrid traits that otherwise segregate. Thus, understanding the controls of meiosis has major implications for both health and crop improvement. How meiotic gene expression is regulated in multicellular eukaryotes to promote entry into and progression through the meiotic program is poorly understood. Here we identify DUET, a protein essential for male meiosis in the model plant Arabidopsis thaliana, as a regulator of meiotic gene expression. We found that DUET is required for proper expression of JAS and TDM1. These genes function in male meiosis, and regulate spindle organization during meiosis II and cell cycle transitions, respectively. Expression of DUET at the end of prophase coincides with the onset of TDM1 expression, and DUET directly binds TDM1, indicating TDM1 is a direct target of DUET. Our results provide an initial framework for further elucidating the developmental and molecular controls of meiotic gene expression in plants.

Vyšlo v časopise: The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene during Male Meiosis in. PLoS Genet 11(9): e32767. doi:10.1371/journal.pgen.1005396
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005396

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