A Virulent Strain of Deformed Wing Virus (DWV) of Honeybees () Prevails after -Mediated, or , Transmission

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Honeybees are the most important managed pollinating insect, contributing billions of dollars to annual global agricultural production. Over the last century a parasitic mite, Varroa, has spread worldwide, with significant impacts on honeybee colony health as a consequence of its transmission of a cocktail of viruses while feeding on honeybee ‘blood’. The most important virus for colony health is deformed wing virus (DWV), high levels of which cause developmental deformities and premature ageing resulting in high overwintering colony losses. In experiments on individual Varroa-exposed pupae we demonstrate that a single type of virulent DWV is amplified 1,000–10,000 times in the recipient pupae, despite the mite containing a high diversity of replicating DWV strains. We could recapitulate this by direct injection of pupae with mixed virus populations, showing the virulent strain is advantaged by the route of transmission. In parallel, we detected changes in the immune response and developmental gene expression of the honeybee and propose that these contribute to the characteristic pathogenesis of DWV. Identification of a virulent strain of DWV has implications for therapeutic or prophylactic interventions to improve honeybee colony health, as well as contributing to our understanding of the biology of this important honeybee viral pathogen.

Vyšlo v časopise: A Virulent Strain of Deformed Wing Virus (DWV) of Honeybees () Prevails after -Mediated, or , Transmission. PLoS Pathog 10(6): e32767. doi:10.1371/journal.ppat.1004230
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004230

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