The Contribution of Social Behaviour to the Transmission of Influenza A in a Human Population

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For infections such as influenza, there are several aspects to the transmission process, including the properties of the pathogen itself, the host immune system and host behaviour. Although it has been proposed that self-reported social mixing patterns can be used to explain the behavioural component of infection – and mathematical modelling studies based on reported social contacts are used routinely to inform health policy – it is not clear how these contacts contribute to individual- and group-level infection risk. By analysing the relationship between social contacts and infection patterns during the 2009 Hong Kong influenza pandemic, we show that infection risk was strongly influenced by the average reported social mixing behaviour of an individual's age group, rather than by their personal reported contacts. We also demonstrate how social contact surveys can be combined with mathematical models to create useful tools with which to study respiratory infections in humans. This should make it possible to predict how the impact of interventions will vary from one population to the next based on their contacts and, potentially, to explain differences in infection attack rates between groups with different mixing behaviours.

Vyšlo v časopise: The Contribution of Social Behaviour to the Transmission of Influenza A in a Human Population. PLoS Pathog 10(6): e32767. doi:10.1371/journal.ppat.1004206
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004206

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