Mitigation of Prion Infectivity and Conversion Capacity by a Simulated Natural Process—Repeated Cycles of Drying and Wetting

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Prion diseases such as chronic wasting disease and scrapie are emerging in North America at an increasing rate. Infectious prions are introduced into the environment from both living and dead animals where they can bind to soil. Little information is available on the effect of prion inactivation under conditions that would be found in the natural environment. In this study, we exposed both unbound and soil-bound prions to repeated cycles of drying and wetting to simulate ambient environmental conditions. We found evidence of prion inactivation in both unbound and soil bound prions. The influence of repeated cycles of drying and wetting are dependent on the prion strain and soil type used and, interestingly, prions bound to soil were more susceptible to inactivation. This is the first report of natural environmental processes mitigating prion infectivity. This data suggests that the total environmental prion load is a balance between input and natural clearance.

Vyšlo v časopise: Mitigation of Prion Infectivity and Conversion Capacity by a Simulated Natural Process—Repeated Cycles of Drying and Wetting. PLoS Pathog 11(2): e32767. doi:10.1371/journal.ppat.1004638
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004638

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