An Effector Peptide Family Required for Toll-Mediated Immunity

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Dedicated defense systems in the bodies of humans and other animals protect against dangerous microbes, such as bacteria and fungi. We study these processes in the fruit fly Drosophila, which can be readily grown and manipulated in the laboratory. In this animal, as in humans, protective activities are triggered when fragments of bacteria or fungi activate a system for defense gene regulation known as the Toll signaling pathway. The result is the large-scale production of defense molecules and, in many cases, clearance of the infection and survival of the animal. Although the systems for recognizing and initiating responses are well described, the role of many defense molecules is not understood. We have identified a group of closely related defense molecules in flies and used state-of-the-art genomic engineering to simultaneously eliminate most of the genes in the group. By comparing the effect of fungal or bacterial infection on the genetically altered flies and normal siblings, we find that this group of defense molecules is essential for disease resistance.

Vyšlo v časopise: An Effector Peptide Family Required for Toll-Mediated Immunity. PLoS Pathog 11(4): e32767. doi:10.1371/journal.ppat.1004876
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004876

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