GATA-Dependent Glutaminolysis Drives Appressorium Formation in by Suppressing TOR Inhibition of cAMP/PKA Signaling

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Many fungal pathogens destroy important crops by first gaining entrance to the host using specialized appressorial cells. Understanding the molecular mechanisms that control appressorium formation could provide new routes for managing severe plant diseases. Here, we describe a previously unknown regulatory pathway that suppresses appressorium formation by the rice pathogen Magnaporthe oryzae. We provide evidence that a mutant M. oryzae strain, unable to form appressoria, accumulates intracellular glutamine that, in turn, inappropriately activates a conserved signaling pathway called TOR. Reducing intracellular glutamine levels, or inactivating TOR, restored appressorium formation to the mutant strain. TOR activation is thus a powerful inhibitor of appressorium formation and could be leveraged to develop sustainable mitigation practices against recalcitrant fungal pathogens.

Vyšlo v časopise: GATA-Dependent Glutaminolysis Drives Appressorium Formation in by Suppressing TOR Inhibition of cAMP/PKA Signaling. PLoS Pathog 11(4): e32767. doi:10.1371/journal.ppat.1004851
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004851

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