An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation

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Vaccines suffice for protecting public health against seasonal influenza viruses, but when unexpected strains appear against which the vaccine does not confer protection, alternative treatments are necessary. In this work, we used gene expression and virus growth data from influenza-infected mice to determine how moderate and deadly influenza viruses may invoke unique inflammatory responses and the role these responses play in disease pathology. We found that the relationship between virus growth and the inflammatory response for all viruses tested can be characterized by ultrasensitive response in which the inflammatory response is gated until a threshold concentration of virus is exceeded in the lung after which strong inflammatory gene expression and cytokine production occurs. This finding challenges the notion that deadly influenza viruses invoke unique cytokine and inflammatory responses and provides additional evidence that pathology is regulated by virus load, albeit in a highly nonlinear fashion. These findings suggests immunomodulatory treatments could focus on altering inflammatory response dynamics to improve disease pathology.

Vyšlo v časopise: An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation. PLoS Pathog 11(6): e32767. doi:10.1371/journal.ppat.1004856
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004856

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