Satellite DNA Modulates Gene Expression in the Beetle after Heat Stress

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Non-coding repetitive DNAs constitute a considerable portion of most eukaryotic genomes and their function is intensively investigated. Here we analyse a gene-regulatory role for tandemly repeated satellite DNA which is the major building element of pericentromeric and centromeric heterochromatin in many eukaryotes. We use as a model system the beetle Tribolium castaneum which has a major satellite DNA preferentially located in pericentromeric heterochromatin but satellite repeats are also dispersed in the vicinity of protein-coding genes within euchromatin. Our results demonstrate for the first time the role of satellite DNA in the modulation of protein-gene expression and reveal the molecular mechanism of their gene-regulatory activity. The influence of satellite DNA on neighbouring genes is epigenetic in nature and is induced by specific changes in the environment such as long-term heat stress. Based on this, the impact of satellite DNAs on adaptation to different environmental conditions as well as their role in the evolution of gene regulatory networks is proposed.

Vyšlo v časopise: Satellite DNA Modulates Gene Expression in the Beetle after Heat Stress. PLoS Genet 11(8): e32767. doi:10.1371/journal.pgen.1005466
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005466

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