GOLPH3 Is Essential for Contractile Ring Formation and Rab11 Localization to the Cleavage Site during Cytokinesis in

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In animal cell cytokinesis, constriction of an actomyosin ring at the equatorial cortex of dividing cells must be finely coordinated with plasma membrane remodeling and vesicle trafficking at the cleavage furrow. Accurate control of these events during cell cleavage is essential for maintaining ploidy and preventing neoplastic transformation. GOLPH3 has been recognized as a potent oncogene, involved in the development of several human tumors. However, the precise roles played by GOLPH3 in tumorigenesis are not yet understood. In this manuscript we demonstrate for the first time the requirement for GOLPH3 for cytokinesis. GOLPH3 protein localizes at the cleavage site of Drosophila dividing cells and is essential for cytokinesis in male meiotic cells and larval neuroblasts. We show that this protein acts as a key molecule in coupling plasma membrane remodeling with actomyosin ring assembly and stability during cytokinesis. Our studies indicate a novel connection between GOLPH3 and the molecular mechanisms of cytokinesis, opening new fields of investigation into the tumor cell biology of this oncogene.

Vyšlo v časopise: GOLPH3 Is Essential for Contractile Ring Formation and Rab11 Localization to the Cleavage Site during Cytokinesis in. PLoS Genet 10(5): e32767. doi:10.1371/journal.pgen.1004305
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004305

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