Heritable Transmission of Stress Resistance by High Dietary Glucose in

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Nutritional state has major effects on health and longevity, and investigations into the mechanisms of dietary restriction have taken the lion's share of recent genetic discoveries. We used Caenorhabditis elegans to investigate the role of diet on nematode physiology and report the surprising finding that exposure to high glucose at one generational time point has heritable effects in descendent progeny. Glucose promotes resistance against cellular stress and neurodegeneration in parental and descendent progeny, while reducing lifespan only in the parental generation. Furthermore, we found that glucose mediated protection is dependent on well-known metabolic and stress response genes. Numerous strategies have evolved to ensure reproductive success in the face of changing and challenging environments. It is believed that extended lifespan phenotypes observed under dietary restriction conditions maximize an organism's survival until environmental conditions improve allowing for reproduction. We discovered a novel diet-influenced reproductive advantage; animals subjected to high dietary glucose are resistant to protein damaging stress, and this resistance is transmitted to their progeny. The trade-off for stress-resistant progeny is decreased lifespan and fecundity in the parental strain suggesting that this strategy may be adaptive under nutrient rich conditions.

Vyšlo v časopise: Heritable Transmission of Stress Resistance by High Dietary Glucose in. PLoS Genet 10(5): e32767. doi:10.1371/journal.pgen.1004346
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004346

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