Memory and Fitness Optimization of Bacteria under Fluctuating Environments

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Bacterial adaptation to new environments typically involves reorganization of gene expression that temporarily decreases growth rates. By exposing cells to fluctuating conditions using an innovative microfluidic device, we discover that E. coli cells can remember past environments, which accelerates their physiological adaptation. Using a modeling approach combined with experiments, we demonstrate the adaptive advantage of memory for organisms that 1) transmit long-lived intracellular proteins between generations or 2) respond to fluctuations in a history-dependent manner. Our work describes one of the simplest examples of adaptive memory in a living organism and provides significant insights into the behavior of genetic networks under diverse fluctuations, including nutrients, antibiotics, and other environmental stresses.

Vyšlo v časopise: Memory and Fitness Optimization of Bacteria under Fluctuating Environments. PLoS Genet 10(9): e32767. doi:10.1371/journal.pgen.1004556
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004556

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