A Re-examination of the Selection of the Sensory Organ Precursor of the Bristle Sensilla of

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The sensory organ precursor cell (SOP) that forms the mechanosensory bristles of the adult PNS of Drosophila is a paradigm to study neural precursor determination. The current model states that the SOP is selected in proneural clusters (PNCs) defined through the expression of the proneural genes. The selection occurs through lateral inhibition mediated by the Notch signalling pathway. The SOP is pre-selected by differential expression of Extramacrochaetae (Emc), the only member of the Id proteins in Drosophila, which inactivates the proneural factors. We have re-examined the selection process using novel markers and mutants. Our data suggest a different picture of SOP selection. We discovered a band–like region of varying proneural activity where the peaks constitute the proneural clusters. Within the PNC, a subgroup exists from which the SOP arises. The Notch pathway has two distinct functions in the subgroup and in the rest of the band. We show that so far one unappreciated essential role of the proneural genes is the neutralisation of the activity of Emc. Our data suggest that the selection of the SOP is more similar to neural selection in vertebrates than previously anticipated.

Vyšlo v časopise: A Re-examination of the Selection of the Sensory Organ Precursor of the Bristle Sensilla of. PLoS Genet 11(1): e32767. doi:10.1371/journal.pgen.1004911
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004911

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