PRDM9 Drives Evolutionary Erosion of Hotspots in through Haplotype-Specific Initiation of Meiotic Recombination

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Sexually reproducing creatures need to produce germ cells, notably sperm and egg, and do so using a specialized cell division, termed meiosis. A hallmark of meiosis is the process of recombination, in which pieces of maternal and paternal genetic material are exchanged, creating new combinations that are inherited by their progeny. Recombination increases diversity in subsequent generations, facilitating evolution. However, if recombination goes awry, it can lead to genetic disorders and spontaneous abortions in humans. In most mammals the sites of recombination are directed by the enzyme PRDM9 to specific regions on DNA, termed hotspots. For several decades it has been speculated that the process of recombination should lead to the eventual inactivation of hotspots, resulting in the loss of ability to reproduce. The discovery of PRDM9 provided a potential solution to this dilemma when the appearance of new PRDM9 alleles with altered DNA binding specificity would immediately create a new set of hotspots. We have now used the power of mouse genetics and large scale measurements of PRDM9 location and activity to show that this cycle of hotspot loss and recovery does indeed occur over the course of hundreds of thousands of years, and is directed by PRDM9.

Vyšlo v časopise: PRDM9 Drives Evolutionary Erosion of Hotspots in through Haplotype-Specific Initiation of Meiotic Recombination. PLoS Genet 11(1): e32767. doi:10.1371/journal.pgen.1004916
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004916

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