Elevated Mutation Rate during Meiosis in

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Meiosis, the cellular division that gives rise to germ cells, contributes to evolution by reassortment of parental alleles. This process involves recombination initiated by Spo11-induced double-strand breaks early in meiosis. The result is that germ cells from a single meiosis are different from either parent. Here we show that the DNA repair associated with meiotic recombination is inherently mutagenic, providing an additional source of variation that can contribute to evolution. This elevated mutagenesis requires the Spo11 protein, and the rate of mutagenesis correlates positively with the frequency of meiotic double-strand breaks. Furthermore, the mutations that arise show an increased level of associated crossovers, consistent with having been introduced during recombination. We speculate that there is an evolutionary drive to position essential genes in meiotic recombination coldspots for slow evolution, and genes that can afford to evolve more rapidly are placed near meiotic recombination hotspots.

Vyšlo v časopise: Elevated Mutation Rate during Meiosis in. PLoS Genet 11(1): e32767. doi:10.1371/journal.pgen.1004910
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004910

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