A Genetic Strategy for Probing the Functional Diversity of Magnetosome Formation

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Model organisms are used to understand biological processes in genetic and molecular detail. However, some interesting processes lack model organisms, and many would benefit from their study in diverse organisms. Bacteria are an enormously diverse domain of life that contains only a few well-studied model systems, making much of their interesting biology inaccessible to genetic or molecular research. Here, we employ a method for performing genetic experiments on non-model organisms that takes advantage of new DNA sequencing technology to work around a lack of genetic tools. We use this method on a non-model organism, Desulfovibrio magneticus RS-1, a member of the magnetotactic bacteria, which construct intracellular nano-sized magnets. The current understanding of magnetotactic bacteria comes from two model organisms that differ from RS-1 in the shape of their magnets and the manner in which the particles are produced. Genetic control over the size and shape of minerals is a poorly understood process and its elucidation has implications for nanotechnological applications. Here, without the need to develop extensive genetic tools for a fastidious organism, we have extended the understanding of the molecular basis of bacterial nano-magnet production.

Vyšlo v časopise: A Genetic Strategy for Probing the Functional Diversity of Magnetosome Formation. PLoS Genet 11(1): e32767. doi:10.1371/journal.pgen.1004811
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004811

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