ETS-4 Is a Transcriptional Regulator of Life Span in

1. KenyonC

ChangJ

GenschE

RudnerA

TabtiangR

1993 A C. elegans mutant that lives twice as long as wild type. Nature 366 461 464

2. PanowskiSH

WolffS

AguilaniuH

DurieuxJ

DillinA

2007 PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447 550 555

3. BudovskayaYV

WuK

SouthworthLK

JiangM

TedescoP

2008 An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 134 291 303

4. OhSW

MukhopadhyayA

SvrzikapaN

JiangF

DavisRJ

2005 JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A 102 4494 4499

5. SheafferKL

UpdikeDL

MangoSE

2008 The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr Biol 18 1355 1364

6. LakowskiB

HekimiS

1998 The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95 13091 13096

7. LeeSS

LeeRY

FraserAG

KamathRS

AhringerJ

2003 A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33 40 48

8. HsinH

KenyonC

1999 Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399 362 366

9. HouthoofdK

VanfleterenJR

2007 Public and private mechanisms of life extension in Caenorhabditis elegans. Mol Genet Genomics 277 601 617

10. MurphyCT

McCarrollSA

BargmannCI

FraserA

KamathRS

2003 Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 277 283

11. MurphyCT

2006 The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Exp Gerontol 41 910 921

12. SharrocksAD

2001 The ETS-domain transcription factor family. Nat Rev Mol Cell Biol 2 827 837

13. GravesBJ

PetersenJM

1998 Specificity within the ets family of transcription factors.

WoudeGV

KleinG

Advances in Cancer Research San Diego Academic Press 1 55

14. MaroulakouIG

BoweDB

2000 Expression and function of Ets transcription factors in mammalian development: a regulatory network. Oncogene 19 6432 6442

15. HollenhorstPC

JonesDA

GravesBJ

2004 Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nucleic Acids Res 32 5693 5702

16. GalangCK

MullerWJ

FoosG

OshimaRG

HauserCA

2004 Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors. J Biol Chem 279 11281 11292

17. FeldmanRJ

SementchenkoVI

GayedM

FraigMM

WatsonDK

2003 Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. Cancer Res 63 4626 4631

18. GuX

ZerbiniLF

OtuHH

BhasinM

YangQ

2007 Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells. Cancer Res 67 4219 4226

19. OettgenP

FingerE

SunZ

AkbaraliY

ThamrongsakU

2000 PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. J Biol Chem 275 1216 1225

20. ChenH

NandiAK

LiX

BieberichCJ

2002 NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. Cancer Res 62 338 340

21. GunawardaneRN

SgroiDC

WrobelCN

KohE

DaleyGQ

2005 Novel role for PDEF in epithelial cell migration and invasion. Cancer Res 65 11572 11580

22. TurnerDP

MoussaO

SauaneM

FisherPB

WatsonDK

2007 Prostate-derived ETS factor is a mediator of metastatic potential through the inhibition of migration and invasion in breast cancer. Cancer Res 67 1618 1625

23. TurnerDP

FindlayVJ

KirvenAD

MoussaO

WatsonDK

2008 Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progression. Mol Biol Cell 19 3745 3757

24. GregorieffA

StangeDE

KujalaP

BegthelH

van den BornM

2009 The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium. Gastroenterology

25. HodgkinJ

1986 Sex determination in the nematode C. elegans: analysis of tra-3 suppressors and characterization of fem genes. Genetics 114 15 52

26. GemsD

RiddleDL

2000 Defining wild-type life span in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 55 B215 219

27. Van VoorhiesWA

WardS

1999 Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate. Proc Natl Acad Sci U S A 96 11399 11403

28. AveryL

1993 The genetics of feeding in Caenorhabditis elegans. Genetics 133 897 917

29. CurranSP

RuvkunG

2007 Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3 e56

30. HartAH

ReventarR

BernsteinA

2000 Genetic analysis of ETS genes in C. elegans. Oncogene 19 6400 6408

31. McKaySJ

JohnsenR

KhattraJ

AsanoJ

BaillieDL

2003 Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans. Cold Spring Harb Symp Quant Biol 68 159 169

32. Reece-HoyesJS

ShinglesJ

DupuyD

GroveCA

WalhoutAJ

2007 Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns. BMC Genomics 8 27

33. MurphyCT

LeeSJ

KenyonC

2007 Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A 104 19046 19050

34. LibinaN

BermanJR

KenyonC

2003 Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115 489 502

35. IserWB

GamiMS

WolkowCA

2007 Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs. Dev Biol 303 434 447

36. HwangboDS

GershmanB

TuMP

PalmerM

TatarM

2004 Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 562 566

37. BroughtonS

PartridgeL

2009 Insulin/IGF-like signalling, the central nervous system and aging. Biochem J 418 1 12

38. WolkowCA

KimuraKD

LeeMS

RuvkunG

2000 Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290 147 150

39. BluherM

KahnBB

KahnCR

2003 Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 572 574

40. GiannakouME

GossM

JungerMA

HafenE

LeeversSJ

2004 Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305 361

41. NonetML

StauntonJE

KilgardMP

FergestadT

HartwiegE

1997 Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. J Neurosci 17 8061 8073

42. SchluterOM

SchmitzF

JahnR

RosenmundC

SudhofTC

2004 A complete genetic analysis of neuronal Rab3 function. J Neurosci 24 6629 6637

43. BeissbarthT

SpeedTP

2004 GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics 20 1464 1465

44. PauliF

LiuY

KimYA

ChenPJ

KimSK

2006 Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Development 133 287 295

45. ReinkeV

SmithHE

NanceJ

WangJ

Van DorenC

2000 A global profile of germline gene expression in C. elegans. Mol Cell 6 605 616

46. RoyPJ

StuartJM

LundJ

KimSK

2002 Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. Nature 418 975 979

47. GaudetJ

MangoSE

2002 Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Science 295 821 825

48. WatsonJD

WangS

Von StetinaSE

SpencerWC

LevyS

2008 Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system. BMC Genomics 9 84

49. SchonesDE

CuiK

CuddapahS

RohTY

BarskiA

2008 Dynamic regulation of nucleosome positioning in the human genome. Cell 132 887 898

50. NyeJA

PetersenJM

GuntherCV

JonsenMD

GravesBJ

1992 Interaction of murine Ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev 6 975 990

51. BadisG

BergerMF

PhilippakisAA

TalukderS

GehrkeAR

2009 Diversity and complexity in DNA recognition by transcription factors. Science 324 1720 1723

52. KoppJL

WilderPJ

DeslerM

KimJH

HouJ

2004 Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the promoter of the type II transforming growth factor-beta receptor gene. J Biol Chem 279 19407 19420

53. BlanchetteM

KentWJ

RiemerC

ElnitskiL

SmitAF

2004 Aligning multiple genomic sequences with the threaded blockset aligner. Genome Res 14 708 715

54. HollenhorstPC

ShahAA

HopkinsC

GravesBJ

2007 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev 21 1882 1894

55. HollenhorstPC

ChandlerKJ

PoulsenRL

JohnsonWE

SpeckNA

2009 DNA specificity determinants associate with distinct transcription factor functions. PLoS Genetics 5 e1000778

56. YangSH

JaffrayE

HayRT

SharrocksAD

2003 Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity. Mol Cell 12 63 74

57. SpiethJ

BlumenthalT

1985 The Caenorhabditis elegans vitellogenin gene family includes a gene encoding a distantly related protein. Mol Cell Biol 5 2495 2501

58. LeeRY

HenchJ

RuvkunG

2001 Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol 11 1950 1957

59. ParadisS

RuvkunG

1998 Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12 2488 2498

60. KenyonC

2005 The plasticity of aging: insights from long-lived mutants. Cell 120 449 460

61. BoehmM

SlackF

2005 A developmental timing microRNA and its target regulate life span in C. elegans. Science 310 1954 1957

62. HsuAL

MurphyCT

KenyonC

2003 Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300 1142 1145

63. LeeSS

KennedyS

TolonenAC

RuvkunG

2003 DAF-16 target genes that control C. elegans life-span and metabolism. Science 300 644 647

64. LiJ

EbataA

DongY

RizkiG

IwataT

2008 Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol 6 e233

65. LithgowGJ

WhiteTM

MelovS

JohnsonTE

1995 Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A 92 7540 7544

66. GemsD

SuttonAJ

SundermeyerML

AlbertPS

KingKV

1998 Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150 129 155

67. HorikawaM

SakamotoK

2009 Fatty-acid metabolism is involved in stress-resistance mechanisms of Caenorhabditis elegans. Biochem Biophys Res Commun 390 1402 1407

68. MabonME

ScottBA

CrowderCM

2009 Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway. PLoS One 4 e7937

69. FinkelT

HolbrookNJ

2000 Oxidants, oxidative stress and the biology of ageing. Nature 408 239 247

70. OliveiraRP

Porter AbateJ

DilksK

LandisJ

AshrafJ

2009 Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8 524 541

71. ParkSK

TedescoPM

JohnsonTE

2009 Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 8 258 269

72. TulletJM

HertweckM

AnJH

BakerJ

HwangJY

2008 Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025 1038

73. LarsenPL

AlbertPS

RiddleDL

1995 Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139 1567 1583

74. OggS

ParadisS

GottliebS

PattersonGI

LeeL

1997 The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389 994 999

75. LinK

DormanJB

RodanA

KenyonC

1997 daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278 1319 1322

76. HendersonST

JohnsonTE

2001 daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11 1975 1980

77. JedlickaP

Gutierrez-HartmannA

2008 Ets transcription factors in intestinal morphogenesis, homeostasis and disease. Histol Histopathol 23 1417 1424

78. McGheeJD

2007 The C. elegans intestine. WormBook 1 36

79. KimbleJ

SharrockWJ

1983 Tissue-specific synthesis of yolk proteins in Caenorhabditis elegans. Dev Biol 96 189 196

80. SchulenburgH

KurzCL

EwbankJJ

2004 Evolution of the innate immune system: the worm perspective. Immunol Rev 198 36 58

81. GhadersohiA

PanD

FayaziZ

HicksDG

WinstonJS

2007 Prostate-derived Ets transcription factor (PDEF) downregulates survivin expression and inhibits breast cancer cell growth in vitro and xenograft tumor formation in vivo. Breast Cancer Res Treat 102 19 30

82. SchaeferJS

SabherwalY

ShiHY

SriramanV

RichardsJ

2010 Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression. J Biol Chem 285 11258 11269

83. PinkstonJM

GariganD

HansenM

KenyonC

2006 Mutations that increase the life span of C. elegans inhibit tumor growth. Science 313 971 975

84. Pinkston-GosseJ

KenyonC

2007 DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet 39 1403 1409

85. BrunetA

2007 Aging and cancer: killing two birds with one worm. Nat Genet 39 1306 1307

86. BrennerS

1974 The genetics of Caenorhabditis elegans. Genetics 77 71 94

87. WicksSR

YehRT

GishWR

WaterstonRH

PlasterkRH

2001 Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nat Genet 28 160 164

88. FergusonEL

HorvitzHR

1989 The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways. Genetics 123 109 121

89. KamathRS

Martinez-CamposM

ZipperlenP

FraserAG

AhringerJ

2001 Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2 RESEARCH0002

90. KamathRS

FraserAG

DongY

PoulinG

DurbinR

2003 Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421 231 237

91. RualJF

CeronJ

KorethJ

HaoT

NicotAS

2004 Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res 14 2162 2168

92. HoogewijsD

De HenauS

DewildeS

MoensL

CouvreurM

2008 The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification. BMC Evol Biol 8 279

93. BreitlingR

ArmengaudP

AmtmannA

HerzykP

2004 Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett 573 83 92

94. HansenM

HsuAL

DillinA

KenyonC

2005 New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1 119 128

95. LeeSJ

KenyonC

2009 Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol 19 715 722