Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate Assembly of Heterochromatin

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Heterochromatin, characterized by the repression of transcription, is a specialized chromatin structure that plays both structural and functional roles on chromosomes. Heterochromatic domains are dynamic, switching between active and inactive states, and this property is used by cells during developmental switches and may generate phenotypic diversity. We have shown that competition between different heterochromatic domains for limiting amounts of a heterochromatin protein, Sir4, plays a critical role in the switch from an active to an inactive state. Previous work has suggested that this switch is regulated by turnover of histone modifications in these regions and our data suggests that modulating Sir4 abundance acts in parallel to these changes to influence the rate of de novo assembly. This work supports a model in which competition between different chromosomal domains is exploited by cells to regulate cell identity.

Vyšlo v časopise: Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate Assembly of Heterochromatin. PLoS Genet 11(11): e32767. doi:10.1371/journal.pgen.1005425
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005425

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