CAPER Is Vital for Energy and Redox Homeostasis by Integrating Glucose-Induced Mitochondrial Functions via ERR-α-Gabpa and Stress-Induced Adaptive Responses via NF-κB-cMYC

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Energy homeostasis is a vital prerequisite for optimal nutrient utilization and prolonged survival in an environment with fluctuating and frequently scarce food resources. Numerous studies have elucidated the important roles of mitochondrial energy in fasting status but less is known about the role of mitochondria in fed status. Two recent studies elucidated the importance of nutrient-induced mitochondrial functions [1,2] in mammalian longevity, but these studies did not either address how these critical nutrient-induced mitochondrial functions are integrated with nutrient-enhanced antioxidant capacities—nor identify how the carbon and nitrogen balance is maintained. Our study reveals CAPER, as the `first’ example of a coregulator nodal integrator which eukaryotes share to orchestrate both nutrient-induced mitochondrial energy metabolism by coactivating ERR-α-Gabpa and stress-induced adaptive metabolic responses via NF- κB/c-Myc; this allows maintenance of carbon-nitrogen balance as well as preservation of life span and reproductive capacity. These metabolic roles for the CAPER coactivator in energy homeostasis are highly conserved and crucial for life span and reproduction in human cells and C. elegans.

Vyšlo v časopise: CAPER Is Vital for Energy and Redox Homeostasis by Integrating Glucose-Induced Mitochondrial Functions via ERR-α-Gabpa and Stress-Induced Adaptive Responses via NF-κB-cMYC. PLoS Genet 11(4): e32767. doi:10.1371/journal.pgen.1005116
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005116

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