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preLekára.sk / Odborné časopisy / PLOS Genetics / 2015 - 4

Multi-locus Analysis of Genomic Time Series Data from Experimental Evolution

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A growing number of experimental biologists are generating “evolve-and-resequence” (E&R) data in which the genomes of an experimental population are repeatedly sequenced over time. The resulting time series data provide important new insights into the dynamics of evolution. This type of analysis has only recently been made possible by next-generation sequencing, and new statistical procedures are required to analyze this novel data source. We present such a procedure here, and apply it to both simulated and real E&R data.

Vyšlo v časopise: Multi-locus Analysis of Genomic Time Series Data from Experimental Evolution. PLoS Genet 11(4): e32767. doi:10.1371/journal.pgen.1005069
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005069

Souhrn

A growing number of experimental biologists are generating “evolve-and-resequence” (E&R) data in which the genomes of an experimental population are repeatedly sequenced over time. The resulting time series data provide important new insights into the dynamics of evolution. This type of analysis has only recently been made possible by next-generation sequencing, and new statistical procedures are required to analyze this novel data source. We present such a procedure here, and apply it to both simulated and real E&R data.

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